Owing to their ability to efficiently generate ATP required to sustain normal cell function,
mitochondria are often considered the 'powerhouses of the cell'. However, our …

Mitochondria not only synthesize energy required for cellular functions but are also involved
in numerous cellular pathways including apoptosis, calcium homoeostasis, inflammation …

The large GTP ase dynamin is the first protein shown to catalyze membrane fission.
Dynamin and its related proteins are essential to many cell functions, from endocytosis to …

The Mx dynamin-like GTPases are key antiviral effector proteins of the type I and type III
interferon (IFN) systems. They inhibit several different viruses by blocking early steps of the …

Dynamin, the founding member of a family of dynamin-like proteins (DLPs) implicated in
membrane remodelling, has a critical role in endocytic membrane fission events. The use of …

Clathrin is a molecular scaffold for vesicular uptake of cargo at the plasma membrane,
where its assembly into cage-like lattices underlies the clathrin-coated pits of classical …

Mitochondria are dynamic organelles that undergo cycles of fission and fusion. The yeast
dynamin-related protein Dnm1 has been localized to sites of mitochondrial division. Using …

Dynamin 1‐like protein (DNM1L) mediates fission of mitochondria and peroxisomes, and
dysfunction of DNM1L has been implicated in several neurological disorders. To study the …

Mitochondria are ancient organelles evolved from bacteria. Over the course of evolution, the
behavior of mitochondria inside eukaryotic cells has changed dramatically, and the …

Dynamin is a mechanochemical GTPase that oligomerizes around the neck of clathrin-
coated pits and catalyses vesicle scission in a GTP-hydrolysis-dependent manner. The …