Scanning probe microscopy

K Bian, C Gerber, AJ Heinrich, DJ Müller… - Nature Reviews …, 2021 - nature.com
Scanning probe microscopy (SPM), a key invention in nanoscience, has by now been
extended to a wide spectrum of basic and applied fields. Its application to basic science led …

Atomic force microscopy-based mechanobiology

M Krieg, G Fläschner, D Alsteens, BM Gaub… - Nature Reviews …, 2019 - nature.com
Mechanobiology emerges at the crossroads of medicine, biology, biophysics and
engineering and describes how the responses of proteins, cells, tissues and organs to …

Imaging modes of atomic force microscopy for application in molecular and cell biology

YF Dufrêne, T Ando, R Garcia, D Alsteens… - Nature …, 2017 - nature.com
Atomic force microscopy (AFM) is a powerful, multifunctional imaging platform that allows
biological samples, from single molecules to living cells, to be visualized and manipulated …

Atomic force microscopy-based force spectroscopy and multiparametric imaging of biomolecular and cellular systems

DJ Müller, AC Dumitru, C Lo Giudice… - Chemical …, 2020 - ACS Publications
During the last three decades, a series of key technological improvements turned atomic
force microscopy (AFM) into a nanoscopic laboratory to directly observe and chemically …

Synthesis, assembly, and applications of hybrid nanostructures for biosensing

S Zhang, R Geryak, J Geldmeier, S Kim… - Chemical …, 2017 - ACS Publications
The robust, sensitive, and selective detection of targeted biomolecules in their native
environment by prospective nanostructures holds much promise for real-time, accurate, and …

Atomic force microscopy-based characterization and design of biointerfaces

D Alsteens, HE Gaub, R Newton… - Nature Reviews …, 2017 - nature.com
Atomic force microscopy (AFM)-based methods have matured into a powerful nanoscopic
platform, enabling the characterization of a wide range of biological and synthetic …

Dynamic monitoring of oscillatory enzyme activity of individual live bacteria via nanoplasmonic optical antennas

D Lu, G Zhu, X Li, J Xiong, D Wang, Y Shi, T Pan… - Nature …, 2023 - nature.com
Outer membrane vesicles (OMVs) are extracellular structures derived from the outer
membrane of bacteria. They carry diverse cargos such as proteins, nucleic acids and …

Nanomechanical mapping of first binding steps of a virus to animal cells

D Alsteens, R Newton, R Schubert… - Nature …, 2017 - nature.com
Viral infection is initiated when a virus binds to cell surface receptors. Because the cell
membrane is dynamic and heterogeneous, imaging living cells and simultaneously …

Cell wall as a target for bacteria inactivation by pulsed electric fields

F Pillet, C Formosa-Dague, H Baaziz, E Dague… - Scientific reports, 2016 - nature.com
The integrity and morphology of bacteria is sustained by the cell wall, the target of the main
microbial inactivation processes. One promising approach to inactivation is based on the …

Effect of actin organization on the stiffness of living breast cancer cells revealed by peak-force modulation atomic force microscopy

A Calzado-Martín, M Encinar, J Tamayo, M Calleja… - ACS …, 2016 - ACS Publications
We study the correlation between cytoskeleton organization and stiffness of three epithelial
breast cancer cells lines with different degrees of malignancy: MCF-10A (healthy), MCF-7 …