Unusual amino acids are fundamental building blocks of modern medicinal chemistry. The
combination of readily functionalized amine and carboxyl groups attached to a chiral central …

Lipid II is a membrane-anchored cell-wall precursor that is essential for bacterial cell-wall
biosynthesis. The effectiveness of targeting Lipid II as an antibacterial strategy is highlighted …

This review covers some of the recent progress in the field of peptide antibiotics with a focus
on compounds with novel or established mode of action and with demonstrated efficacy in …

A review of efforts that have provided total syntheses of vancomycin and related
glycopeptide antibiotics, their agylcons, and key analogues is provided. It is a tribute to …

Re-engineering biosynthetic assembly lines, including nonribosomal peptide synthetases
(NRPS) and related megasynthase enzymes, is a powerful route to new antibiotics and other …

Ever since the world‐shaping discovery of penicillin, nature's molecular diversity has been
extensively screened for new medications and lead compounds in drug discovery. The …

Covering: up to 2017 History points to the bacterial cell wall biosynthetic network as a very
effective target for antibiotic intervention, and numerous natural product inhibitors have been …

Covering: 2000 up to 2020 This review presents select recent advances in the medicinal
chemistry of complex natural products that are prepared by total synthesis. The underlying …

Cyclic lipopeptides (CLPs) are a promising class of natural products with antibiotic
properties. CLPs are amphiphilic molecules, composed of a fatty acid tail linked to a short …

The lipoglycodepsipeptide antibiotic ramoplanin is proposed to inhibit bacterial cell wall
biosynthesis by binding to intermediates along the pathway to mature peptidoglycan, which …