Modified nucleosides, nucleotides and nucleic acids via click azide-alkyne cycloaddition for pharmacological applications
D Perrone, E Marchesi, L Preti, ML Navacchia - Molecules, 2021 - mdpi.com
The click azide= alkyne 1, 3-dipolar cycloaddition (click chemistry) has become the
approach of choice for bioconjugations in medicinal chemistry, providing facile reaction …
approach of choice for bioconjugations in medicinal chemistry, providing facile reaction …
Synthesis and biological properties of triazole-linked locked nucleic acid
We have synthesized and studied the biological and biophysical properties of triazole-linked
ribo and xylo locked nucleic acid (LNA). The combination of LNA with the Isobe triazole …
ribo and xylo locked nucleic acid (LNA). The combination of LNA with the Isobe triazole …
Triazole-linked nucleic acids: Synthesis, therapeutics and synthetic biology applications
This article covers the triazole-linked nucleic acids where the triazole linkage (TL) replaces
the natural phosphate backbone. The replacement is done at either a few selected linkages …
the natural phosphate backbone. The replacement is done at either a few selected linkages …
Locked nucleic acid (LNA) enhances binding affinity of triazole-linked DNA towards RNA
P Kumar, AH El-Sagheer, L Truong… - Chemical …, 2017 - pubs.rsc.org
Oligonucleotides containing internal triazole–3′-LNA linkages bind to complementary RNA
with similar affinity and specificity to unmodified oligonucleotides, and significantly better …
with similar affinity and specificity to unmodified oligonucleotides, and significantly better …
Synthesis, affinity for complementary RNA and DNA, and enzymatic stability of triazole-linked locked nucleic acids (t-LNAs)
Dinucleoside phosphoramidites containing a triazole internucleotide linkage flanked by
locked nucleic acid (LNA) were synthesized and incorporated into oligonucleotides (ONs) …
locked nucleic acid (LNA) were synthesized and incorporated into oligonucleotides (ONs) …
Chimeric RNA oligonucleotides incorporating triazole-linked trinucleotides: synthesis and function as mRNA in cell-free translation reactions
A method for the synthesis of chimeric oligonucleotides was developed to incorporate purine
nucleobases and multiple triazole linkers in natural, phosphate-linked structures of RNA. A …
nucleobases and multiple triazole linkers in natural, phosphate-linked structures of RNA. A …
Duplex‐forming Oligonucleotide of Triazole‐linked RNA
An oligonucleotide of triazole‐linked RNA (TLRNA) was synthesized by performing
consecutive copper‐catalyzed azide‐alkyne cycloaddition reactions for elongation. The …
consecutive copper‐catalyzed azide‐alkyne cycloaddition reactions for elongation. The …
Design and Synthesis of Sugar-modified Triazole-linked Dinucleosides.
Two sugar-modified triazole-linked nonionic dinucleosides T< sup> L-tT< sup> OX and A<
sup> BzL-tT< sup> OX have been designed and synthesized by Cu (I)-catalyzed Huisgen …
sup> BzL-tT< sup> OX have been designed and synthesized by Cu (I)-catalyzed Huisgen …
[引用][C] 9-Trimethylsilyl-N,N-bis(trimethylsilyl)adenine
BA Gostevskii, AI Albanov, NF Lazareva - Russian Chemical Bulletin, 2024 - Springer
Adenine (6-aminopurine) and its derivatives play an important role in biochemical processes
occurring in living organisms. In particular, some adenine derivatives (6-benzylaminopurine …
occurring in living organisms. In particular, some adenine derivatives (6-benzylaminopurine …