Variants in> 12 genes encoding sarcomeric proteins can cause various cardiomyopathies.
The two most common are hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy …

The primary etiology of a diverse range of cardiomyopathies is now understood to be
genetic, creating a new paradigm for targeting treatments on the basis of the underlying …

Hypertrophic cardiomyopathy (HCM) affects more than 1 in 500 people in the general
population with an extensive burden of morbidity in the form of arrhythmia, heart failure, and …

Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) allow investigations in a
human cardiac model system, but disorganized mechanics and immaturity of hPSC-CMs on …

Hypertrophic cardiomyopathy (HCM) is the most prevalent genetically inherited
cardiomyopathy that follows an autosomal dominant inheritance pattern. The majority of …

Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are considered
immature in the sarcomere organization, contractile machinery, calcium transient, and …

Background: Pathogenic variants in MYBPC3, encoding cardiac MyBP-C (myosin binding
protein C), are the most common cause of familial hypertrophic cardiomyopathy. A large …

Skeletal muscle, a highly complex muscle type in the eukaryotic system, is characterized by
different muscle subtypes and functions associated with specific myosin isoforms. As a …

Mutations in atrial-enriched genes can cause a primary atrial myopathy that can contribute to
overall cardiovascular dysfunction. MYBPHL encodes myosin-binding protein H-like (MyBP …

Genetic cardiomyopathies have been studied for decades, and it has become increasingly
clear that these progressive diseases are more complex than originally thought. These …