Cancer is a dysregulated cellular level pathological condition that results in tumor formation
followed by metastasis. In the heterogeneous tumor architecture, cancer stem cells (CSCs) …

Tumors are not merely cancerous cells that undergo mindless proliferation. Rather, they are
highly organized and interconnected organ systems. Tumor cells reside in complex …

BACKGROUND Epidemiologic studies suggest that metformin has antitumor effects.
Laboratory studies indicate metformin impacts cancer stem-like cells (CSCs). As part of a …

Within the ovarian cancer tumor microenvironment, cancer stem-like cells (CSC) interact
with carcinoma associated mesenchymal stem/stromal cells (CA-MSC) through multiple …

Background Liver cancer is the second most common cause of cancer-related death. Every
type of tumours including liver cancer contains cancer stem cells (CSCs). To date, the …

Simple Summary The Warburg effect in cancer cells (high glucose update and lactate
release) is an adaptation that is considered a hallmark of most neoplasms. Blocking …

The PI3K/AKT pathway is a key target in oncology where most efforts are focussed on
phenotypes such as cell proliferation and survival. Comparatively, little attention has been …

Intraperitoneal dissemination of ovarian cancers is preceded by the development of
chemoresistant tumors with malignant ascites. Despite the high levels of chemoresistance …

Ovarian cancer remains a deadly diagnosis with an 85% recurrence rate and a 5-year
survival rate of only 46%. The poor outlook of this disease has improved little over the past …

Metastatic cancers are chemoresistant, involving complex interplay between disseminated
cancer cell aggregates and the distant organ microenvironment (extracellular matrix and …