Serotonergic mechanisms in spinal cord injury

FE Perrin, HN Noristani - Experimental neurology, 2019 - Elsevier
Spinal cord injury (SCI) is a tragic event causing irreversible losses of sensory, motor, and
autonomic functions, that may also be associated with chronic neuropathic pain. Serotonin …

Voluntary activation of muscle in humans: does serotonergic neuromodulation matter?

JJ Kavanagh, JL Taylor - The Journal of physiology, 2022 - Wiley Online Library
Ionotropic inputs to motoneurones have the capacity to depolarise and hyperpolarise the
motoneurone, whereas neuromodulatory inputs control the state of excitability of the …

Enhanced availability of serotonin increases activation of unfatigued muscle but exacerbates central fatigue during prolonged sustained contractions

JJ Kavanagh, AJ McFarland… - The Journal of …, 2019 - Wiley Online Library
Key points Animal preparations have revealed that moderate synaptic release of serotonin
(5‐HT) onto motoneurones enhances motor activity via activation of 5‐HT2 receptors …

Enhanced availability of serotonin limits muscle activation during high-intensity, but not low-intensity, fatiguing contractions

TT Henderson, JL Taylor… - Journal of …, 2022 - journals.physiology.org
Serotonin (5-HT) modulates motoneuron excitability during muscle contractions, where the
release of 5-HT in the central nervous system (CNS) is linked to the intensity of physical …

[HTML][HTML] Serotonergic and noradrenergic contributions to motor cortical and spinal motoneuronal excitability in humans

JR Thorstensen, TT Henderson, JJ Kavanagh - Neuropharmacology, 2024 - Elsevier
Animal models indicate that motor behaviour is shaped by monoamine neuromodulators
released diffusely throughout the brain and spinal cord. As an alternative to conducting a …

Enhanced serotonin availability amplifies fatigue perception and modulates the TMS‐induced silent period during sustained low‐intensity elbow flexions

JR Thorstensen, JL Taylor, MG Tucker… - The Journal of …, 2020 - Wiley Online Library
Key points During maximal effort contractions, intense serotonin release via the raphe‐
spinal pathway spills over from the somato‐dendritic compartment to activate inhibitory 5 …

Serotonergic modulation of locomotor activity from basal vertebrates to mammals

A Flaive, M Fougère, CI Van der Zouwen… - Frontiers in Neural …, 2020 - frontiersin.org
During the last 50 years, the serotonergic (5-HT) system was reported to exert a complex
modulation of locomotor activity. Here, we focus on two key factors that likely contribute to …

Effects of α-lactalbumin on strength, fatigue and psychological parameters: a randomised double-blind cross-over study

K Mackay-Phillips, LBR Orssatto, R Polman… - European Journal of …, 2023 - Springer
Purpose The neurotransmitter serotonin has a strong effect on behaviour and motor control.
Regarding motor control, serotonin contributes to the development of fatigue and is also …

Analysis of the anti-fatigue activity of polysaccharides from Spirulina platensis: role of central 5-hydroxytryptamine mechanisms

M Zhu, H Zhu, X Ding, S Liu, Y Zou - Food & function, 2020 - pubs.rsc.org
This study evaluated the effects of polysaccharides from Spirulina platensis (PSP) on
endurance during treadmill exercise; levels of some biochemical indicators including …

Estimates of persistent inward currents in lower limb muscles are not different between inactive, resistance-trained, and endurance-trained young males

V Goreau, F Hug, A Jannou… - Journal of …, 2024 - journals.physiology.org
Persistent inward currents (PICs) increase the intrinsic excitability of α-motoneurons. The
main objective of this study was to compare estimates of α-motoneuronal PICs between …