Making sense of the ageing methylome
Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …
been associated with a broad range of age-related diseases, including cardiovascular …
DNA methylation-based predictors of health: applications and statistical considerations
DNA methylation data have become a valuable source of information for biomarker
development, because, unlike static genetic risk estimates, DNA methylation varies …
development, because, unlike static genetic risk estimates, DNA methylation varies …
Genetic impacts on DNA methylation: research findings and future perspectives
S Villicaña, JT Bell - Genome biology, 2021 - Springer
Multiple recent studies highlight that genetic variants can have strong impacts on a
significant proportion of the human DNA methylome. Methylation quantitative trait loci, or …
significant proportion of the human DNA methylome. Methylation quantitative trait loci, or …
70-year legacy of the Framingham Heart Study
Abstract The Framingham Heart Study (FHS) was established in 1948 to improve
understanding of the epidemiology of coronary heart disease (CHD) in the USA. In 1961 …
understanding of the epidemiology of coronary heart disease (CHD) in the USA. In 1961 …
Cognitive impairment and dementia after stroke: design and rationale for the DISCOVERY study
Stroke is a leading cause of the adult disability epidemic in the United States, with a major
contribution from poststroke cognitive impairment and dementia (PSCID), the rates of which …
contribution from poststroke cognitive impairment and dementia (PSCID), the rates of which …
Blood leukocyte DNA methylation predicts risk of future myocardial infarction and coronary heart disease: a longitudinal study of 11 461 participants from population …
Background: DNA methylation is implicated in coronary heart disease (CHD), but current
evidence is based on small, cross-sectional studies. We examined blood DNA methylation …
evidence is based on small, cross-sectional studies. We examined blood DNA methylation …
Genome-wide identification of DNA methylation QTLs in whole blood highlights pathways for cardiovascular disease
Identifying methylation quantitative trait loci (meQTLs) and integrating them with disease-
associated variants from genome-wide association studies (GWAS) may illuminate …
associated variants from genome-wide association studies (GWAS) may illuminate …
Toward precision medicine: circadian rhythm of blood pressure and chronotherapy for hypertension-2021 NHLBI workshop report
Healthy individuals exhibit blood pressure variation over a 24-hour period with higher blood
pressure during wakefulness and lower blood pressure during sleep. Loss or disruption of …
pressure during wakefulness and lower blood pressure during sleep. Loss or disruption of …
Physical activity is associated with slower epigenetic ageing—Findings from the Rhineland study
Epigenetic ageing, ie, age‐associated changes in DNA methylation patterns, is a sensitive
marker of biological ageing, a major determinant of morbidity and functional decline. We …
marker of biological ageing, a major determinant of morbidity and functional decline. We …
Arsenic exposure, blood DNA methylation, and cardiovascular disease
A Domingo-Relloso, K Makhani… - Circulation …, 2022 - Am Heart Assoc
Background: Epigenetic dysregulation has been proposed as a key mechanism for arsenic-
related cardiovascular disease (CVD). We evaluated differentially methylated positions …
related cardiovascular disease (CVD). We evaluated differentially methylated positions …