Pain-resolving immune mechanisms in neuropathic pain

NT Fiore, SR Debs, JP Hayes, SS Duffy… - Nature Reviews …, 2023 - nature.com
Interactions between the immune and nervous systems are of central importance in
neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or …

Unsaturated fatty acids and their immunomodulatory properties

S Coniglio, M Shumskaya, E Vassiliou - Biology, 2023 - mdpi.com
Simple Summary Diet can influence human health in both positive and negative ways. Ω-3
polyunsaturated fatty acids have an overall positive effect on humans. The sources of these …

Isoliquiritigenin mitigates oxidative damage after subarachnoid hemorrhage in vivo and in vitro by regulating Nrf2-dependent Signaling Pathway via Targeting of …

JQ Liu, XT Zhao, FY Qin, JW Zhou, F Ding, G Zhou… - Phytomedicine, 2022 - Elsevier
Background Oxidative stress is a crucial factor leading to subarachnoid hemorrhage (SAH)-
induced early brain injury (EBI). Isoliquiritigenin has been verified as a powerful anti-oxidant …

[HTML][HTML] Resolution of inflammation via RvD1/FPR2 signaling mitigates Nox2 activation and ferroptosis of macrophages in experimental abdominal aortic aneurysms

AC Filiberto, Z Ladd, V Leroy, G Su… - … : official publication of …, 2022 - ncbi.nlm.nih.gov
Abdominal aortic aneurysm (AAA) formation is characterized by inflammation, leukocyte
infiltration, and vascular remodeling. Resolvin D1 (RvD1) is derived from ω-3 …

Specialized Pro-Resolving Lipid Mediators: Endogenous Roles and Pharmacological Activities in Infections

FS Rasquel-Oliveira, MDV Silva, G Martelossi-Cebinelli… - Molecules, 2023 - mdpi.com
During an infection, inflammation mobilizes immune cells to eliminate the pathogen and
protect the host. However, inflammation can be detrimental when exacerbated and/or …

Formyl peptide receptor 2, as an important target for ligands triggering the inflammatory response regulation: a link to brain pathology

K Tylek, E Trojan, M Regulska, E Lacivita… - Pharmacological …, 2021 - Springer
Formyl peptide receptors (FPRs) belong to the family of seven-transmembrane G protein-
coupled receptors. Among them, FPR2 is a low affinity receptor for N-formyl peptides and is …

PDK4 Decrease Neuronal Apoptosis via Inhibiting ROS-ASK1/P38 Pathway in Early Brain Injury After Subarachnoid Hemorrhage

X Gao, YY Gao, HY Yan, GJ Liu, Y Zhou… - Antioxidants & Redox …, 2022 - liebertpub.com
Aims: Metabolic disorders may play key roles in oxidative stress and neuronal apoptosis in
response to early brain injury (EBI) after subarachnoid hemorrhage (SAH). Pyruvate …

Resolvin D1: A key endogenous inhibitor of neuroinflammation

A Roohbakhsh, L Etemad, G Karimi - Biofactors, 2022 - Wiley Online Library
After the initiation of inflammation, a series of processes start to resolve the inflammation. A
group of endogenous lipid mediators, namely specialized pro‐resolving lipid mediators is at …

The role of the blood neutrophil-to-lymphocyte ratio in aneurysmal subarachnoid hemorrhage

L Cai, H Zeng, X Tan, X Wu, C Qian, G Chen - Frontiers in Neurology, 2021 - frontiersin.org
Aneurysmal subarachnoid hemorrhage (aSAH) is an important type of stroke with the
highest rates of mortality and disability. Recent evidence indicates that neuroinflammation …

Neuroprotective strategies in aneurysmal subarachnoid hemorrhage (aSAH)

J Weiland, A Beez, T Westermaier, E Kunze… - International journal of …, 2021 - mdpi.com
Aneurysmal subarachnoid hemorrhage (aSAH) remains a disease with high mortality and
morbidity. Since treating vasospasm has not inevitably led to an improvement in outcome …