Organized extracellular matrix (ECM), in the form of aligned architectures, is a critical
mediator of directed cancer cell migration by contact guidance, leading to metastasis in solid …

Second harmonic generation (SHG) and third harmonic generation (THG) microscopies
have emerged as powerful imaging modalities to examine structural properties of a wide …

Pancreatic ductal adenocarcinoma (PDA) is an extremely metastatic and lethal disease.
Here, in both murine and human PDA, we demonstrate that extracellular matrix architecture …

Second harmonic generation (SHG) microscopy is acknowledged as an established
imaging technique capable to provide information on the collagen architecture in tissues that …

The majority of high-grade serous ovarian cancers originate in the fallopian tubes, however,
the corresponding structural changes in the extracellular matrix (ECM) have not been well …

Papillary thyroid carcinoma (PTC) is one of the most common, well-differentiated carcinomas
of the thyroid gland. PTC nodules are often surrounded by a collagen capsule that prevents …

Neoadjuvant chemotherapy (NACT) is routinely administered to subsets of breast cancer
patients, including triple negative (TN) or human epidermal growth factor receptor 2-positive …

The lung is a biomechanically active organ, with multiscale mechanical forces impacting the
organ, tissue and cellular responses within this microenvironment. In chronic lung diseases …

Introduction Structural changes in the collagen II architecture of osteoarthritis (OA) are poorly
understood, which is a large shortcoming in the early diagnosis of this disease. Though …

Tumors, their microenvironment, and the mechanisms by which collagen morphology
changes throughout cancer progression have recently been a topic of interest. Second …