DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy

R Huang, PK Zhou - Signal transduction and targeted therapy, 2021 - nature.com
Genomic instability is the hallmark of various cancers with the increasing accumulation of
DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is …

Pitfalls in the diagnosis of nodular lymphocyte predominant Hodgkin lymphoma: variant patterns, borderlines and mimics

S Younes, RB Rojansky, JR Menke, D Gratzinger… - Cancers, 2021 - mdpi.com
Simple Summary Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a rare
lymphoma containing infrequent tumor cells (LP cells) in a background of non-neoplastic …

CDK9 inhibition induces epigenetic reprogramming revealing strategies to circumvent resistance in lymphoma

E Thieme, N Bruss, D Sun, EC Dominguez… - Molecular Cancer, 2023 - Springer
Diffuse large B-cell lymphoma (DLBCL) exhibits significant genetic heterogeneity which
contributes to drug resistance, necessitating development of novel therapeutic approaches …

Mitochondrial pyruvate supports lymphoma proliferation by fueling a glutamate pyruvate transaminase 2–dependent glutaminolysis pathway

P Wei, AJ Bott, AA Cluntun, JT Morgan… - Science …, 2022 - science.org
The fate of pyruvate is a defining feature in many cell types. One major fate is mitochondrial
entry via the mitochondrial pyruvate carrier (MPC). We found that diffuse large B cell …

[HTML][HTML] SPARC-positive macrophages are the superior prognostic factor in the microenvironment of diffuse large B-cell lymphoma and independent of MYC …

GA Croci, RKH Au-Yeung, S Reinke, AM Staiger… - Annals of …, 2021 - Elsevier
Background Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease with
respect to outcome. Features of the tumor microenvironment (TME) are associated with …

Spatially-resolved transcriptomics reveal macrophage heterogeneity and prognostic significance in diffuse large B-cell lymphoma

M Liu, G Bertolazzi, S Sridhar, RX Lee… - Nature …, 2024 - nature.com
Macrophages are abundant immune cells in the microenvironment of diffuse large B-cell
lymphoma (DLBCL). Macrophage estimation by immunohistochemistry shows varying …

Lymphoma Microenvironment in DLBCL and PTCL-NOS: the key to uncovering heterogeneity and the potential for stratification

K Miyawaki, T Sugio - Journal of clinical and experimental …, 2022 - jstage.jst.go.jp
Diffuse large B-cell lymphoma (DLBCL) and peripheral T-cell lymphoma, not otherwise
specified (PTCL-NOS) are the most common subtypes of mature B cell neoplasm and T/NK …

Bone marrow lymphoid niche adaptation to mature B cell neoplasms

E Dumontet, SJC Mancini, K Tarte - Frontiers in Immunology, 2021 - frontiersin.org
B-cell non-Hodgkin lymphoma (B-NHL) evolution and treatment are complicated by a high
prevalence of relapses primarily due to the ability of malignant B cells to interact with tumor …

Genetic mechanisms underlying tumor microenvironment composition and function in diffuse large B-cell lymphoma

L Cerchietti - Blood, 2024 - ashpublications.org
Cells in the tumor microenvironment (TME) of diffuse large B-cell lymphoma (DLBCL) show
enormous diversity and plasticity, with functions that can range from tumor inhibitory to tumor …

A bone-based 3D scaffold as an in-vitro model of microenvironment–DLBCL lymphoma cell interaction

J Ceccato, M Piazza, M Pizzi, S Manni, F Piazza… - Frontiers in …, 2022 - frontiersin.org
About 30% of patients with diffuse large B-cell lymphoma (DLBCL) relapse or exhibit
refractory disease (r/r DLBCL) after first-line immunochemotherapy. Bone marrow (BM) …