Molybdenum is the only second-row transition metal required by most living organisms, and
is nearly universally distributed in biology. Enzymes containing molybdenum in their active …

Molybdenum cofactor (Moco) biosynthesis is an ancient, ubiquitous, and highly conserved
pathway leading to the biochemical activation of molybdenum. Moco is the essential …

The unicellular soil-freshwater alga Chlamydomonas reinhardtii was found to secrete
substances that mimic the activity of the N-acyl-l-homoserine lactone (AHL) signal molecules …

Archaea, one of three major evolutionary lineages of life, encode proteasomes highly
related to those of eukaryotes. In contrast, archaeal ubiquitin-like proteins are less …

The biosynthesis of the molybdenum cofactor in bacteria is described with a detailed
analysis of each individual reaction leading to the formation of stable intermediates during …

Based on our recent work with Haloferax volcanii, ubiquitin-like (Ubl) proteins (SAMP1 and
SAMP2) are known to be covalently attached to proteins in archaea. Here, we investigated …

The concept of the minimal cell has fascinated scientists for a long time, from both
fundamental and applied points of view. This broad concept encompasses extreme …

Dimethyl sulfoxide reductases (DMSO) are molybdoenzymes widespread in all domains of
life. They catalyse not only redox reactions, but also hydroxylation/hydration and oxygen …

The molybdenum cofactor is an important cofactor, and its biosynthesis is essential for many
organisms, including humans. Its basic form comprises a single molybdopterin (MPT) unit …

We have purified and characterized a specific CTP: molybdopterin cytidylyltransferase for
the biosynthesis of the molybdopterin (MPT) cytosine dinucleotide (MCD) cofactor in …