During severe inflammatory and infectious diseases, various mediators modulate the
equilibrium of vascular tone, inflammation, coagulation and thrombosis. This Review …

The role of renin-angiotensin-aldosterone system in the progression of chronic kidney
disease The renin-angiotensin-aldosterone system (RAAS) is a well known regulator of …

Interruption of the renin–angiotensin–aldosterone system has become a leading therapeutic
strategy in the treatment of chronic heart and kidney disease. Angiotensin-converting …

Background The aim of this study was to assess dual renin system intervention with the
maximum recommended doses of aliskiren and valsartan, compared with each drug alone …

The renin–angiotensin system (RAS) plays a critical role in the development of diabetic
nephropathy, and blockade of the RAS is currently used for treatment of diabetic …

Use of drugs that inhibit the renin-angiotensin system is an effective way to intervene in the
pathogenesis of cardiovascular and renal disorders. The idea of blocking the renin system at …

A collective century of discoveries establishes the importance of the renin angiotensin
aldosterone system in maintaining blood pressure, fluid volume and electrolyte homeostasis …

Objectives Aliskiren is a novel, orally active renin inhibitor. Its antihypertensive efficacy and
safety, alone and in combination with hydrochlorothiazide (HCTZ), were investigated in an 8 …

Objectives: This dose-ranging study evaluated the antihypertensive efficacy and tolerability
of aliskiren in patients with mild-to-moderate hypertension. Background: Low blood pressure …

With the development of aliskiren, blockade of the renin–angiotensin–aldosterone system
(RAAS) at the level of the interaction of renin with a substrate has become a clinical reality …