[HTML][HTML] How to use biomarkers of infection or sepsis at the bedside: guide to clinicians

P Póvoa, L Coelho, F Dal-Pizzol, R Ferrer… - Intensive care …, 2023 - Springer
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to infection. In this context, biomarkers could be considered as indicators of either …

Biomarkers of sepsis

JD Faix - Critical reviews in clinical laboratory sciences, 2013 - Taylor & Francis
Sepsis is an unusual systemic reaction to what is sometimes an otherwise ordinary infection,
and it probably represents a pattern of response by the immune system to injury. A hyper …

Machine-learning-based electronic triage more accurately differentiates patients with respect to clinical outcomes compared with the emergency severity index

S Levin, M Toerper, E Hamrock, JS Hinson… - Annals of emergency …, 2018 - Elsevier
Study objective Standards for emergency department (ED) triage in the United States rely
heavily on subjective assessment and are limited in their ability to risk-stratify patients. This …

[HTML][HTML] Diagnostic accuracy of procalcitonin, neutrophil-lymphocyte count ratio, C-reactive protein, and lactate in patients with suspected bacterial sepsis

L Ljungström, AK Pernestig, G Jacobsson… - PloS one, 2017 - journals.plos.org
Background Early recognition is a key factor to achieve improved outcomes for septic
patients. Combinations of biomarkers, as opposed to single ones, may improve timely …

[HTML][HTML] Sepsis biomarkers: a review

C Pierrakos, JL Vincent - Critical care, 2010 - Springer
Introduction Biomarkers can be useful for identifying or ruling out sepsis, identifying patients
who may benefit from specific therapies or assessing the response to therapy. Methods We …

New approaches to sepsis: molecular diagnostics and biomarkers

K Reinhart, M Bauer, NC Riedemann… - Clinical microbiology …, 2012 - Am Soc Microbiol
Sepsis is among the most common causes of death in hospitals. It arises from the host
response to infection. Currently, diagnosis relies on nonspecific physiological criteria and …

Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding

KN Iskander, MF Osuchowski… - Physiological …, 2013 - journals.physiology.org
Sepsis represents the host's systemic inflammatory response to a severe infection. It causes
substantial human morbidity resulting in hundreds of thousands of deaths each year …

The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer

S Chakraborty, S Kaur, S Guha, SK Batra - Biochimica et Biophysica Acta …, 2012 - Elsevier
Neutrophil gelatinase associated lipocalin (NGAL), also known as oncogene 24p3,
uterocalin, siderocalin or lipocalin 2, is a 24kDa secreted glycoprotein originally purified …

Graphene enabled low‐noise surface chemistry for multiplexed sepsis biomarker detection in whole blood

U Zupančič, P Jolly, P Estrela… - Advanced Functional …, 2021 - Wiley Online Library
Affinity‐based electrochemical (EC) sensors offer a potentially valuable approach for point‐
of‐care (POC) diagnostics applications, and for the detection of diseases, such as sepsis …

[HTML][HTML] Circulating microRNAs as biomarkers for sepsis

F Benz, S Roy, C Trautwein, C Roderburg… - International journal of …, 2016 - mdpi.com
Sepsis represents a major cause of lethality during intensive care unit (ICU) treatment.
Pharmacological treatment strategies for sepsis are still limited and mainly based on the …