Mechanisms of taxane resistance

SM Maloney, CA Hoover, LV Morejon-Lasso… - Cancers, 2020 - mdpi.com
Simple Summary Drug resistance is prevalent in many types of cancer and decreases
patient survival. The taxanes are anti-mitotic chemotherapeutic agents, widely used since …

DREAM on: cell cycle control in development and disease

H Walston, AN Iness, L Litovchick - Annual review of genetics, 2021 - annualreviews.org
Perfectly orchestrated periodic gene expression during cell cycle progression is essential for
maintaining genome integrity and ensuring that cell proliferation can be stopped by …

Integrated analysis of telomerase enzymatic activity unravels an association with cancer stemness and proliferation

N Noureen, S Wu, Y Lv, J Yang, WK Alfred Yung… - Nature …, 2021 - nature.com
Active telomerase is essential for stem cells and most cancers to maintain telomeres. The
enzymatic activity of telomerase is related but not equivalent to the expression of TERT, the …

Analysis of m6A RNA methylation-related genes in liver hepatocellular carcinoma and their correlation with survival

Y Li, D Qi, B Zhu, X Ye - International Journal of Molecular Sciences, 2021 - mdpi.com
N6-methyladenosine (m6A) modification on RNA plays an important role in tumorigenesis
and metastasis, which could change gene expression and even function at multiple levels …

The oncogenic kinase NEK2 regulates an RBFOX2-dependent pro-mesenchymal splicing program in triple-negative breast cancer cells

C Naro, M De Musso, F Delle Monache… - Journal of Experimental …, 2021 - Springer
Background Triple-negative breast cancer (TNBC) is the most heterogeneous and malignant
subtype of breast cancer (BC). TNBC is defined by the absence of expression of estrogen …

Role of NEK2 in tumorigenesis and tumor progression

J Xia, H Zhao, JL Edmondson, B Koss… - Trends in Molecular …, 2024 - cell.com
Never in mitosis A (NIMA)-related kinase 2 (NEK2) is a serine/threonine kinase found in the
nucleus and cytoplasm throughout the cell cycle. NEK2 is overexpressed in many cancers …

Kinase inhibitors for precision therapy of triple-negative breast cancer: Progress, challenges, and new perspectives on targeting this heterogeneous disease

D Mehlich, AA Marusiak - Cancer Letters, 2022 - Elsevier
Triple-negative breast cancer (TNBC) is a highly heterogeneous disease that encompasses
a subset of breast cancers that are defined by the absence of expression of the estrogen …

One shoot, three birds: Targeting NEK2 orchestrates chemoradiotherapy, targeted therapy, and immunotherapy in cancer treatment

X Huang, G Zhang, T Tang, X Gao, T Liang - Biochimica et Biophysica Acta …, 2022 - Elsevier
Combinational therapy has improved the cancer therapeutic landscape but is associated
with a concomitant increase in adverse side reactions. Emerging evidence proposes that …

Thermo-mechanical coupling simulation analysis of cryotherapy on real anatomical structure lung cancer model

X Wang, X Li, W Rao - International Journal of Thermal Sciences, 2024 - Elsevier
Cryotherapy is an ideally invasive way for lung cancer. Conventional cryoablation treatment
lacks precise treatment plans and evaluation methods, relying on medical images for …

Recent advances in drug discovery for triple-negative breast cancer treatment

D Masci, C Naro, M Puxeddu, A Urbani, C Sette… - Molecules, 2023 - mdpi.com
Triple-negative breast cancer (TNBC) is one of the most heterogeneous and aggressive
breast cancer subtypes with a high risk of death on recurrence. To date, TNBC is very …