Neutrophils or polymorphonuclear leukocytes (PMN) are key participants in the innate
immune response for their ability to execute different effector functions. These cells express …

Polymorphonuclear leukocytes or neutrophils play a critical role in the maintenance of
intestinal homeostasis. They have elegant defense mechanisms to eliminate microbes that …

Background Nuclear factor (erythroid-derived 2) factor 2 (Nrf2) is a crucial transcription factor
mediating protection against oxidants. Nrf2 is negatively regulated by cytoplasmic Kelch-like …

Cells constantly generate reactive oxygen species (ROS) during aerobic metabolism. The
ROS generation plays an important protective and functional role in the immune system. The …

Neutrophil extracellular traps (NETs) are extracellular structures composed of chromatin and
granule proteins that bind and kill microorganisms. We show that upon stimulation, the …

During phagocytosis of microbial intruders, professional phagocytes of our innate immune
system increase their oxygen consumption through the activity of an NADPH-oxidase that …

Cells are constantly generating reactive oxygen species (ROS) during aerobic metabolism.
As a consequence, each cell is equipped with an extensive antioxidant defence system to …

Neutrophils are the most abundant of all white blood cells in the human circulation and are
usually associated with inflammation and with fighting infections. In recent years the role …

Although the central role of the phagocytic NADPH oxidase in mediating bacterial killing has
long been appreciated, this sophisticated enzyme complex serves various other important …

Mesenchymal stem cells (MSCs) are crucial for tissue homeostasis and regeneration.
Though of prime interest, their potentially protective role on neutrophil-induced tissue …