Antibiotic treatment of tuberculosis takes≥ 6 months, putting a major burden on patients and
health systems in large parts of the world. Treatment beyond 2 months is needed to prevent …

Bacterial infections remain a major threat to humanity and are a leading cause of death and
disability. Antimicrobial resistance has been declared as one of the top ten threats to human …

Tuberculous meningitis (TB meningitis) is the most severe form of tuberculosis (TB),
requiring 12 months of multidrug treatment for cure, and is associated with high morbidity …

Pretomanid is a nitroimidazole antimicrobial active against drug-resistant Mycobacterium
tuberculosis and approved in combination with bedaquiline and linezolid (BPaL) to treat …

Despite concerted efforts over the past 2 decades at developing new diagnostics, drugs, and
vaccines with expanding pipelines, tuberculosis remains a global emergency. Several novel …

Bacterial biofilm formation is a major complication of implantable medical devices that
results in therapeutically challenging chronic infections, especially in cases involving …

Background Several nonclinical drug-development tools (DDTs) have been used for
antituberculosis drug development over several decades. The role of the DDTs used for …

Infectious diseases are a major threat to humanity, and it is imperative that we develop
imaging tools that aid in their study, facilitate diagnosis, and guide treatment. The alarming …

Rationale: Our current understanding of tuberculosis (TB) pathophysiology is limited by a
reliance on animal models, the paucity of human TB lung tissue, and traditional …

Central nervous system (CNS) tuberculosis (TB) is the most severe form of extra-pulmonary
TB and disproportionately affects young children where the developing brain has a unique …