Neurodegenerative diseases (NDDs) are irreversible, progressive diseases with no effective
treatment. The hallmark of NDDs is the aggregation of misfolded, modified proteins, which …

One of the more transformative findings in human genetics was the discovery that the
expansion of unstable nucleotide repeats underlies a group of inherited neurological …

Sustaining DNA damage response (DDR) signalling via retention of DDR factors at
damaged sites is important for transmitting damage-sensing and repair signals. Herein, we …

Treatments targeting oncogenic fusion proteins are notable examples of successful drug
development. Abnormal splicing of genes resulting in fusion proteins is a critical driver of …

Huntington's disease (HD) is caused by an expanded CAG repeat in the huntingtin gene,
yielding a Huntingtin protein with an expanded polyglutamine tract. While experiments with …

Allergic asthma is characterized by goblet cell metaplasia and subsequent mucus
hypersecretion that contribute to the morbidity and mortality of this disease. Here, we explore …

The gaseous neurotransmitter hydrogen sulfide (H2S) exerts neuroprotective efficacy in the
brain via post‐translational modification of cysteine residues by sulfhydration, also known as …

Background A major challenge in neurodegenerative diseases concerns identifying
biological disease signatures that track with disease progression or respond to an …

Protein SUMOylation is a major post-translational modification essential for maintaining
cellular homeostasis. SUMOylation has long been associated with stress responses as a …

Small ubiquitin-like modifier (SUMO) plays a key regulatory role in cardiovascular diseases,
such as cardiac hypertrophy, hypertension, atherosclerosis, and cardiac ischemia …