The use of biomarkers in diagnosis, therapy and prognosis has gained increasing interest
over the last decades. In particular, the analysis of biomarkers in cancer patients within the …

Estrogen receptor-positive (ER+) breast cancer is the most common breast cancer subtype.
Treatment of ER+ breast cancer comprises interventions that suppress estrogen production …

The horizontal transfer of mtDNA and its role in mediating resistance to therapy and an exit
from dormancy have never been investigated. Here we identified the full mitochondrial …

Breast cancer is the most frequently diagnosed cancer in women, with estrogen receptor
positive (ER+) breast cancer making up approximately 75% of all breast cancers diagnosed …

Lack of sensitive single-cell analysis tools has limited the characterization of metabolic
activity in cancer stem cells. By hyperspectral-stimulated Raman scattering imaging of single …

The Notch signaling pathway plays an essential role in a wide variety of biological
processes including cell fate determination of vascular endothelial cells and the regulation …

Abstract Development of therapeutic resistance and metastasis is a major challenge with
current breast cancer (BC) therapy. Mounting evidence suggests that a subpopulation of …

Current standard-of-care (SOC) therapy for breast cancer includes targeted therapies such
as endocrine therapy for estrogen receptor-alpha (ERα) positive; anti-HER2 monoclonal …

Breast cancer is the most frequent type of malignancy in women worldwide, and drug
resistance to the available systemic therapies remains a major challenge. At the molecular …

Cancer treatment with either standard chemotherapy or targeted agents often results in the
emergence of drug-refractory cell populations, ultimately leading to therapy failure. The …