Azathioprine (brand names Imuran, Azasan) is an immunosuppressant that belongs to the
drug class of thiopurines. It is used with other drugs to prevent kidney transplant rejection …

Polygenic models have emerged as promising prediction tools for the prediction of complex
traits. Currently, the majority of polygenic models are developed in the context of predicting …

Background Fluoropyrimidine plus platinum chemotherapy remains the standard first line
treatment for gastric cancer (GC). Guidelines exist for the clinical interpretation of four DPYD …

Mercaptopurine (brand names Purinethol, Purixan) is an immunosuppressant and anti-
neoplastic agent that belongs to the drug class of thiopurines. It is used with other drugs to …

Patients with inflammatory bowel disease (IBD) show large variability in disease course, and
also treatment response. The variability in treatment response has led to many initiatives in …

Precision medicine aims to personalize treatment for both effectiveness and safety. As a
critical component of this emerging initiative, pharmacogenomics seeks to guide drug …

Thioguanine (brand name Tabloid) is used to treat acute nonlymphocytic leukemias, such as
acute myeloid leukemia (AML). Thioguanine is an analogue of the nucleic acid guanine and …

Polymorphisms thiopurine-S-methyltransferase (TPMT) and nudix hydrolase 15 (NUDT15)
can increase the risk of azathioprine myelotoxicity, but little is known about other genetic …

Anthracyclines and cisplatin are two widely-used chemotherapeutic agents in the treatment
of pediatric cancers. However, their use is limited by severe life-threatening and life-altering …

Background: Fluoropyrimidine plus platinum chemotherapy remains the standard first line
treatment for gastric cancer (GC). Guidelines exist for the clinical interpretation of four DPYD …