Hepatocellular carcinoma (HCC) is the fifth most common cancer and the second leading
cause of cancer-related deaths worldwide. Although the prognosis of patients with HCC is …

An early diagnosis of hepatocellular carcinoma (HCC) followed by effective treatment is
currently critical for improving the prognosis and reducing the associated economic burden …

AXL is a member of the TAM (TYRO3, AXL, and MERTK) receptor tyrosine kinases family
(RTKs), and its abnormal expression has been linked to clinicopathological features and …

The AXL receptor tyrosine kinase (AXL) has emerged as a promising therapeutic target for
cancer therapy. Recent studies have revealed a central role of AXL signaling in tumor …

The most common primary liver cancer is hepatocellular carcinoma (HCC), and its mortality
rate is increasing globally. The overall 5-year survival of patients with liver cancer is …

Proteases known as sheddases cleave the extracellular domains of their substrates from the
cell surface. The A Disintegrin and Metalloproteinases ADAM10 and ADAM17 are among …

Background Early diagnosis is crucial for patients with pancreatic ductal adenocarcinoma
(PDAC). The AXL receptor tyrosine kinase is proteolytically processed releasing a soluble …

AXL is a tyrosine kinase membrane receptor that signals via PI3K, MAPK, and protein kinase
C (PKC), among other pathways. AXL has oncogenic potential and interacts with other …

Hepatocellular carcinoma (HCC) is the most common liver malignancy and a leading cause
of cancer-related mortality worldwide. Accurate detection and differential diagnosis of early …

The expression of the receptor tyrosine kinase Axl and its cleavage product soluble Axl
(sAxl) is increased in liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). In this …