The diagnostic use of procalcitonin for bacterial infections remains a matter of debate. Most
studies have used ambiguous outcome measures such as sepsis instead of infection. We …

Point-of-care testing (POCT) is the analysis of patient specimens outside the clinical
laboratory, near or at the site of patient care, usually performed by clinical staff without …

Background The knowledge that persistent human papillomavirus (HPV) infection is the
main cause of cervical cancer has resulted in the development of prophylactic vaccines to …

An elevated white blood cell count has many potential etiologies, including malignant and
nonmalignant causes. It is important to use age-and pregnancy-specific normal ranges for …

A survey of doctors working in two large NHS hospitals identified over 120 laboratory tests,
imaging investigations and investigational procedures that they considered not to be …

Bacterial and viral infections are often clinically indistinguishable, leading to inappropriate
patient management and antibiotic misuse. Bacterial-induced host proteins such as …

Fever in children is a common concern for parents and one of the most frequent presenting
complaints in emergency department visits, often involving non-pediatric emergency …

Objectives Identifying infection aetiology is essential for appropriate antibiotic use. Previous
studies have shown that a host-protein signature consisting of TNF-related apoptosis …

Importance Rapid and accurate diagnosis of late-onset infection in newborn infants could
inform treatment decisions and avoid unnecessary administration of antibiotics. Objective To …

Background The prescription rate of antibiotics is high for febrile children visiting the
emergency department (ED), contributing to antimicrobial resistance. Large studies at …