Acute pain signaling has a key protective role and is highly evolutionarily conserved.
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …

Pre-diabetes and diabetes are a global epidemic, and the associated neuropathic
complications create a substantial burden on both the afflicted patients and society as a …

Diabetic neuropathy is a common complication of both type 1 and type 2 diabetes, which
affects over 90% of the diabetic patients. Although pain is one of the main symptoms of …

The transmission and processing of pain signals relies critically on the activities of ion
channels that are expressed in afferent pain fibers. This includes voltage-gated channels, as …

This study establishes a mechanism for metabolic hyperalgesia based on the glycolytic
metabolite methylglyoxal. We found that concentrations of plasma methylglyoxal above 600 …

Neuropathy will afflict over half of the estimated 460 million people worldwide who have
diabetes, 303 of whom approximately onethird will also develop neuropathic pain. 2 The …

Nociception is essential for survival whereas pathological pain is maladaptive and often
unresponsive to pharmacotherapy. Voltage-gated sodium channels, Nav1. 1–Nav1. 9, are …

The persistence of increased excitability and spontaneous activity in injured peripheral
neurons is imperative for the development and persistence of many forms of neuropathic …

Long-term diabetes increases the likelihood of developing secondary damage to numerous
systems, and these complications represent a substantial cause of morbidity and mortality …

Acute, inflammatory, and neuropathic pain can all be attenuated or abolished by local
treatment with sodium channel blockers such as lidocaine. The peripheral input that drives …