Type 1 diabetes (T1D) is a T cell–mediated autoimmune disease characterized by the
destruction of insulin‐secreting pancreatic β cells. In humans with T1D and in nonobese …

Cancer is one of the most devastating disorders in our lives. Higher rate of proliferation than
death of cells is one of the essential factors for development of cancer. The dynamicity of cell …

Without a doubt, rodent models have been instrumental in describing pathways that lead to
pancreatic β-cell destruction, evaluating potential causes of type 1 diabetes and providing …

Apoptosis of beta cells is a feature of both type 1 and type 2 diabetes as well as loss of islets
after transplantation. In type 1 diabetes, beta cells are destroyed by immunological …

Type 1 diabetes mellitus (T1D) is characterized by severe insulin deficiency resulting from
chronic and progressive destruction of pancreatic beta-cells by the immune system. The …

Beta cell loss occurs at the onset of type 1 diabetes and after islet graft. It results from the
dysfunction and destruction of beta cells mainly achieved by apoptosis. One of the mediators …

Abstract Type 1 diabetes (T1D), an autoimmune disease once thought to be mediated
exclusively by β cell-specific CD4+ T cells, is now recognized as one in which autoreactive …

The “nonclassic” role of 1, 25‐dihydroxyvitamin D3 (1, 25 (OH) 2D3) has been recently
widely recognized. In type 1 diabetes mellitus (T1D), it plays an immunomodulatory role …

A substantial proportion of the transplanted islet mass fails to engraft due to death by
apoptosis, and a number of strategies have been explored to inhibit β-cell loss. Inhibition of …

Aims/hypothesis Pancreatic beta cells respond to endoplasmic reticulum (ER) stress by
activating the unfolded protein response. If the stress is prolonged, or the adaptive response …