Systems biology in cardiovascular disease: a multiomics approach
Omics techniques generate large, multidimensional data that are amenable to analysis by
new informatics approaches alongside conventional statistical methods. Systems theories …
new informatics approaches alongside conventional statistical methods. Systems theories …
The role of voltage-gated sodium channels in pain signaling
Acute pain signaling has a key protective role and is highly evolutionarily conserved.
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …
Genetic associations of protein-coding variants in human disease
Genome-wide association studies (GWAS) have identified thousands of genetic variants
linked to the risk of human disease. However, GWAS have so far remained largely …
linked to the risk of human disease. However, GWAS have so far remained largely …
[HTML][HTML] Cardiac transmembrane ion channels and action potentials: cellular physiology and arrhythmogenic behavior
Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …
Early-onset atrial fibrillation and the prevalence of rare variants in cardiomyopathy and arrhythmia genes
ZT Yoneda, KC Anderson, JA Quintana… - JAMA …, 2021 - jamanetwork.com
Importance Early-onset atrial fibrillation (AF) can be the initial manifestation of a more
serious underlying inherited cardiomyopathy or arrhythmia syndrome. Objective To examine …
serious underlying inherited cardiomyopathy or arrhythmia syndrome. Objective To examine …
Epidemiology and genetics of sudden cardiac death
R Deo, CM Albert - Circulation, 2012 - Am Heart Assoc
Sudden cardiac death (SCD) generally refers to an unexpected death from a cardiovascular
cause in a person with or without preexisting heart disease. The specificity of this definition …
cause in a person with or without preexisting heart disease. The specificity of this definition …
Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death
CR Bezzina, J Barc, Y Mizusawa, CA Remme… - Nature …, 2013 - nature.com
Brugada syndrome is a rare cardiac arrhythmia disorder, causally related to SCN5A
mutations in around 20% of cases,,. Through a genome-wide association study of 312 …
mutations in around 20% of cases,,. Through a genome-wide association study of 312 …
Sudden cardiac death prediction and prevention: report from a National Heart, Lung, and Blood Institute and Heart Rhythm Society Workshop
Despite the significant decline in coronary artery disease (CAD) mortality in the second half
of the 20th century, 1 sudden cardiac death (SCD) continues to claim 250 000 to 300 000 …
of the 20th century, 1 sudden cardiac death (SCD) continues to claim 250 000 to 300 000 …
Genetics of sudden cardiac death
CR Bezzina, N Lahrouchi, SG Priori - Circulation research, 2015 - Am Heart Assoc
Sudden cardiac death occurs in a broad spectrum of cardiac pathologies and is an important
cause of mortality in the general population. Genetic studies conducted during the past 20 …
cause of mortality in the general population. Genetic studies conducted during the past 20 …
Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci
JS Kooner, D Saleheen, X Sim, J Sehmi, W Zhang… - Nature …, 2011 - nature.com
We carried out a genome-wide association study of type-2 diabetes (T2D) in individuals of
South Asian ancestry. Our discovery set included 5,561 individuals with T2D (cases) and …
South Asian ancestry. Our discovery set included 5,561 individuals with T2D (cases) and …