Combating bacterial infections with host defense peptides: Shifting focus from bacteria to host immunity

N Gao, J Wang, C Fang, P Bai, Y Sun, W Wu… - Drug Resistance …, 2024 - Elsevier
The increasing prevalence of multidrug-resistant bacterial infections necessitates the
exploration of novel paradigms for anti-infective therapy. Antimicrobial peptides (AMPs), also …

The effects of oxidative stress on the development of atherosclerosis

M Khosravi, A Poursaleh, G Ghasempour… - Biological …, 2019 - degruyter.com
Atherosclerosis is a cardiovascular disease (CVD) known widely world wide. Several
hypothesizes are suggested to be involved in the narrowing of arteries during process of …

Roles of peroxiredoxins in cancer, neurodegenerative diseases and inflammatory diseases

MH Park, MR Jo, YR Kim, CK Lee, JT Hong - Pharmacology & Therapeutics, 2016 - Elsevier
Peroxiredoxins (PRDXs) are antioxidant enzymes, known to catalyze peroxide reduction to
balance cellular hydrogen peroxide (H 2 O 2) levels, which are essential for cell signaling …

Redox biology of the intestine

ML Circu, TY Aw - Free radical research, 2011 - Taylor & Francis
The intestinal tract, known for its capability for self-renew, represents the first barrier of
defence between the organism and its luminal environment. The thiol/disulfide redox …

[HTML][HTML] Multiple roles of peroxiredoxins in inflammation

B Knoops, V Argyropoulou, S Becker, L Ferté… - Molecules and cells, 2016 - Elsevier
Inflammation is a pathophysiological response to infection or tissue damage during which
high levels of reactive oxygen and nitrogen species are produced by phagocytes to kill …

Apelin protects heart against ischemia/reperfusion injury in rat

XJ Zeng, LK Zhang, HX Wang, LQ Lu, LQ Ma, CS Tang - Peptides, 2009 - Elsevier
Apelin, the endogenous ligand of the G protein-coupled APJ receptor, is a peptide mediator
with emerging regulatory actions in the heart. We aimed to determine whether the …

The orphan nuclear receptor SHP acts as a negative regulator in inflammatory signaling triggered by Toll-like receptors

JM Yuk, DM Shin, HM Lee, JJ Kim, SW Kim, HS Jin… - Nature …, 2011 - nature.com
The orphan nuclear receptor SHP (small heterodimer partner) is a transcriptional
corepressor that regulates hepatic metabolic pathways. Here we identified a role for SHP as …

S-nitrosylation of peroxiredoxin 2 promotes oxidative stress-induced neuronal cell death in Parkinson's disease

J Fang, T Nakamura, DH Cho, Z Gu… - Proceedings of the …, 2007 - National Acad Sciences
Peroxiredoxins (Prx), a family of peroxidases that reduce intracellular peroxides with the
thioredoxin system as the electron donor, are highly expressed in various cellular …

Protein corona of magnetic hydroxyapatite scaffold improves cell proliferation via activation of mitogen-activated protein kinase signaling pathway

Y Zhu, Q Yang, M Yang, X Zhan, F Lan, J He, Z Gu… - ACS …, 2017 - ACS Publications
The beneficial effect of magnetic scaffolds on the improvement of cell proliferation has been
well documented. Nevertheless, the underlying mechanisms about the magnetic scaffolds …

Comparative single-cell profiling reveals distinct cardiac resident macrophages essential for zebrafish heart regeneration

KH Wei, IT Lin, K Chowdhury, KL Lim, KT Liu, TM Ko… - Elife, 2023 - elifesciences.org
Zebrafish exhibit a robust ability to regenerate their hearts following injury, and the immune
system plays a key role in this process. We previously showed that delaying macrophage …