T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells

HR Kim, YV Mun, KS Lee, YJ Park, JS Park… - Nature …, 2018 - nature.com
Microvilli on T cells have been proposed to survey surfaces of antigen-presenting cells
(APC) or facilitate adhesion under flow; however, whether they serve essential functions …

Relating enhancer genetic variation across mammals to complex phenotypes using machine learning

IM Kaplow, AJ Lawler, DE Schäffer, C Srinivasan… - Science, 2023 - science.org
Protein-coding differences between species often fail to explain phenotypic diversity,
suggesting the involvement of genomic elements that regulate gene expression such as …

ERVWE1 reduces hippocampal neuron density and impairs dendritic spine morphology through inhibiting Wnt/JNK non-canonical pathway via miR-141-3p in …

W Yao, P Zhou, Q Yan, X Wu, Y Xia, W Li, X Li, F Zhu - Viruses, 2023 - mdpi.com
Human endogenous retroviruses (HERVs) are remnants of ancestral germline infections by
exogenous retroviruses. Human endogenous retroviruses W family envelope gene (HERV …

VSTM5 is a novel immune checkpoint that promotes oral tolerance of cell-mediated and antibody responses

OE Oludada, TO Idowu, Y Jeon, I Choi - Biochemical and Biophysical …, 2022 - Elsevier
The V-set and transmembrane domain-containing protein (VSTM) family is a newly
discovered immunoglobulin (Ig) superfamily that shares structural similarities with the B7 …

Insulin-like growth factor 1 partially rescues early developmental defects caused by SHANK2 knockdown in human neurons

ST Chen, WJ Lai, WJ Zhang, QP Chen… - Neural Regeneration …, 2020 - journals.lww.com
SHANK2 is a scaffold protein that serves as a protein anchor at the postsynaptic density in
neurons. Genetic variants of SHANK2 are strongly associated with synaptic dysfunction and …

[HTML][HTML] Epigenetic regulation of cardiac tissue development by lysine lactylation

X Luan, R Du, G Su, C Yan, X Ren, K Ju, Y Jin, Y An… - hLife, 2025 - Elsevier
Heart disease stands as the foremost global cause of mortality. In rodents, the heart
possesses the remarkable ability for cardiac regeneration within the first 7 days post-birth …

[HTML][HTML] Elucidation of molecular processes and biomarkers linked to the genetic variations driving the etiology of mood disorders

HD Nguyen, GH Vu, WK Kim - Personalized Medicine in Psychiatry, 2024 - Elsevier
Objectives We aimed to identify the significant genetic variations and molecular mechanisms
associated with the pathogenesis of mood disorders associated with genetic variants …

Gene of the month: VSTM2A

L Wang, O Yilmaz, BA Veeneman, Y Zhang… - Journal of Clinical …, 2024 - jcp.bmj.com
The V-set and transmembrane domain containing 2A (VSTM2A) gene is located on
chromosome 7. In the physiological state, VSTM2A regulates preadipocyte cell …

Gene expression in the amygdala and hippocampus of cyclic and acyclic gilts

HR Wijesena, DJ Nonneman, BN Keel… - Journal of Animal …, 2022 - academic.oup.com
Age at first estrus is the earliest phenotypic indicator of future reproductive success of gilts.
Prebreeding anestrus is a major reason for reproductive failure leading to culling of …

A preliminary investigation on plasma cell adhesion molecules levels by protein microarray technology in major depressive disorder

W Liu, Y Zheng, F Zhang, M Zhu, Q Guo, H Xu… - Frontiers in …, 2021 - frontiersin.org
Objectives: Major depressive disorder (MDD) is a serious mental disorder, and there is a
great difficulty to diagnose and treat. Hitherto, relatively few studies have explored the …