[HTML][HTML] Possible mechanism of metabolic and drug resistance with L-asparaginase therapy in childhood leukaemia
R Zhou, T Liang, T Li, J Huang, C Chen - Frontiers in Oncology, 2023 - frontiersin.org
L-asparaginase, which hydrolyzes asparagine into aspartic acid and ammonia, is frequently
used to treat acute lymphoblastic leukaemia in children. When combined with other …
used to treat acute lymphoblastic leukaemia in children. When combined with other …
Metabolism in stem cell–driven leukemia: parallels between hematopoiesis and immunity
KM Rattigan, MM Zarou… - Blood, The Journal of the …, 2023 - ashpublications.org
Our understanding of cancer metabolism spans from its role in cellular energetics and
supplying the building blocks necessary for proliferation, to maintaining cellular redox and …
supplying the building blocks necessary for proliferation, to maintaining cellular redox and …
[HTML][HTML] Alterations in cellular metabolisms after TKI therapy for Philadelphia chromosome-positive leukemia in children: A review
C Li, L Wen, J Dong, L Li, J Huang, J Yang… - Frontiers in …, 2022 - frontiersin.org
Incidence rates of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive
(Ph+) acute lymphoblastic leukemia (ALL) are lower but more aggressive in children than in …
(Ph+) acute lymphoblastic leukemia (ALL) are lower but more aggressive in children than in …
Successful bridging to cell therapy for relapsed/refractory acute lymphoblastic leukaemia with a combination of venetoclax and PEG‐asparaginase.
L Goursaud, C Berthon… - British Journal of …, 2023 - search.ebscohost.com
Successful bridging to cell therapy for relapsed/refractory acute lymphoblastic leukaemia
with a combination of venetoclax and PEG-asparaginase Keywords: cell therapy; leukaemia; …
with a combination of venetoclax and PEG-asparaginase Keywords: cell therapy; leukaemia; …
[HTML][HTML] Key role of glutamine metabolism in persistence of leukemic cells upon exposition to FLT3 tyrosine kinase inhibitors
R Khamari, C Degand, Q Fovez, A Trinh… - Experimental …, 2024 - Elsevier
Highlights•AML-surviving iFLT3 relies on mitochondrial metabolism, mainly glutamine
oxidation.•iFLT3 and asparaginase synergize, targeting resistant AML cells.•iFLT3 and …
oxidation.•iFLT3 and asparaginase synergize, targeting resistant AML cells.•iFLT3 and …