Glaucoma, a major cause of blindness worldwide, is a neurodegenerative optic neuropathy
in which vision loss is caused by loss of retinal ganglion cells (RGCs). To better define the …

Axonal degeneration is one of the initial steps in many traumatic and neurodegenerative
central nervous system (CNS) disorders and thus a promising therapeutic target. A focal …

Nerve injuries can be tantamount to severe impairment, standard treatment such as the use
of autograft or surgery comes with complications and confers a shortened relief. The …

Almost all tumors harbor a defective negative feedback loop of signaling by transforming
growth factor-β (TGF-β). Epigenetic mechanisms of gene regulation, including DNA …

Purpose Elevated intraocular pressure (IOP) is a major risk factor for glaucoma. One
consequence of raised IOP is that ocular tissues are subjected to increased hydrostatic …

US9539259B2 - Compounds and methods of use thereof for treating neurodegenerative
disorders - Google Patents US9539259B2 - Compounds and methods of use thereof for treating …

Background Our previous studies indicated that heat stress can cause significant damage to
the intestinal epithelium and induce differential expression of many genes in rat small …

Traumatic brain injury is a major health problem with much of its morbidity associated with
traumatic axonal injury (TAI). To date, significant insight has been gained into the initiating …