Arginase, a binuclear manganese metalloenzyme in the urea, catalyzes the hydrolysis of L-
arginine to urea and L-ornithine. Both isoforms, arginase 1 and arginase 2 perform …

Calcific aortic valve disease (CAVD) is the end result of active cellular processes that lead to
the progressive fibrosis and calcification of aortic valve leaflets. In western populations …

Cardiovascular diseases (CVD) are the leading cause of global mortality and their
pathogenesis lies mainly in the atherosclerotic process. There are close connections linking …

Calcific aortic valve stenosis (CAVS), the most common heart valve disease, is characterized
by the slow progressive fibro-calcific remodeling of the valve leaflets, leading to progressive …

Calcific aortic valve disease (CAVD) is prevalent in developed nations and has emerged as
a pressing global public health concern due to population aging. The precise etiology of this …

Despite the elucidation of the pathways behind the development of aortic stenosis (AS),
there remains no effective medical treatment to slow or reverse its progress. Instead, the …

Aortic valve stenosis secondary to aortic valve calcification is the most common valve
disease in the Western world. Calcification is a result of pathological proliferation and …

Calcific aortic stenosis is a disorder that impacts the physiology of heart valves. Fibrocalcific
events progress in conjunction with thickening of the valve leaflets. Over the years, these …

Background Calcific aortic valve disease (CAVD) is the most prevalent valvular disease
worldwide. However, no effective treatment could delay or prevent the progression of the …

Vascular calcification is a high incidence and high risk disease with increasing morbidity
and high mortality, which is considered the consequence of smooth muscle cell …