In mammals, many classes of noncoding RNAs (ncRNAs) are expressed at a much higher
level in the brain than in other organs. Recent studies have identified a new class of ncRNAs …

The ubiquitin-proteasome system (UPS) is one of the major protein degradation pathways,
where abnormal UPS function has been observed in cancer and neurological diseases …

The ubiquitin-proteasome system (UPS) is a crucial protein degradation system in
eukaryotes. Herein, we will review advances in the understanding of the role of several …

Neuritic plaques in the brain are a major neuropathological hallmark of Alzheimer's disease.
They are formed by the deposition and aggregation of extracellular amyloid-β protein (Aβ) …

UCHL1 is a multifunctional protein expressed at high concentrations in neurons in the brain
and spinal cord. UCHL1 plays important roles in regulating the level of cellular free ubiquitin …

The aberrant accumulation of β‐amyloid peptide (Aβ) in the brain is a key feature of
Alzheimer's disease (AD), and enhanced cleavage of β‐amyloid precursor protein (APP) by …

INTRODUCTION Contributing to the pathogenesis of Alzheimer's disease (AD),
oligomerized amyloid-β peptide (Aβ), neuronal hyperexcitability, and aging-associated …

Breast cancer has the highest incidence and death rate among cancers in women
worldwide. In particular, metastatic estrogen receptor negative (ER–) breast cancer and …

Amyloid-beta (Abeta) peptide is the original causative factor of Alzheimer's disease (AD)
according to the amyloid cascade hypothesis. The ubiquitin–proteasome system (UPS), the …

The G protein coupled receptors (GPCRs) have been considered as one of the largest
families of validated drug targets, which involve in almost overall physiological functions and …