Total tumor clearance through immunotherapy is associated with a fully coordinated innate
and adaptive immune response, but knowledge on the exact contribution of each immune …

Radiotheranostics is a rapidly growing approach in personalized medicine, merging
diagnostic imaging and targeted radiotherapy to allow for the precise detection and …

The origins of cancer vaccines date back to the 1800s. Since then, there have been
significant efforts to generate vaccines against solid and hematologic malignancies using a …

Glioblastoma (GBM) is a highly malignant intracranial tumor with limited treatment options.
Bispecific T‐cell engagers (BiTEs) are being explored for GBM treatment, but their success …

Small cell lung cancer (SCLC) is an aggressive disease with limited treatment options.
Fucosyl-GM1 (FucGM1) is a glycolipid overexpressed in the majority of SCLC tumors but …

The advent of immune checkpoint inhibition has revolutionized treatment of advanced
melanoma. While most patients derive survival benefit from established immunotherapies …

Background CD3 bispecific antibody (CD3 bsAb) therapy has become an established
treatment modality for some cancer types and exploits endogenous T cells irrespective of …

Garcia et al. discover a novel immunotherapy approach by engineering naturally occurring
mutations in therapeutic T cells to strongly elevate anti‐tumor activity. The authors identify a …

The immune system plays a crucial role in recognizing and combating tumors. Recent
developments in immunotherapy show that we can stimulate the immune system to achieve …

The development of anti-drug antibodies (ADAs) against therapeutic monoclonal antibodies
(mAbs) poses significant challenges in the efficacy and safety of these treatments. ADAs can …