Hedgehog (Hh) signaling pathway plays an essential role during vertebrate embryonic
development and tumorigenesis. It is already known that Sonic hedgehog (Shh) pathway is …

Neural stem cells in the adult mammalian brain are the source of new neurons that
contribute to complex sensory and cognitive functions. Most adult neural stem cells are …

Adult stem cells (SCs) transit between the cell cycle and a poorly defined quiescent state.
Single neural SCs (NSCs) with quiescent, primed-for-activation, and activated cell …

Neural stem cells (NSCs) represent a remarkable developmental unit, necessary for the
proper functioning of neurogenesis, by retaining their plasticity to self-renew and give rise to …

Deciphering the mechanisms that regulate the quiescence of adult neural stem cells (NSCs)
is crucial for the development of therapeutic strategies based on the stimulation of their …

Quiescence in cancer cells is considered a therapeutic challenge as it confers dormancy in
tumour, hence circumventing inherent anti-neoplastic surveillance system and standard-of …

Because of the limited regenerative ability of the central nervous system (CNS), effective
treatments for spinal cord injury (SCI) are still lacking. After SCI, neuron loss and axon …

Neural stem cell (NSC) based therapies are at the forefront of regenerative medicine
strategies to combat illness and injury of the central nervous system (CNS). In addition to …

Neural development requires a series of cellular events starting with cell specification,
proliferation, and migration. Subsequently, axons and dendrites project from the cell surface …

Hippocampal seizures mimicking mesial temporal lobe epilepsy cause a profound
disruption of the adult neurogenic niche in mice. Seizures provoke neural stem cells to …