Recent studies have revealed widespread mRNA alternative polyadenylation (APA) in
eukaryotes and its dynamic spatial and temporal regulation. APA not only generates …

The 3′‐ends of almost all eukaryotic mRNAs are formed in a two‐step process, an
endonucleolytic cleavage followed by polyadenylation (the addition of a poly‐adenosine or …

Cryptococcus neoformans is a pathogenic basidiomycetous yeast responsible for more than
600,000 deaths each year. It occurs as two serotypes (A and D) representing two varieties …

Abstract mRNA polyadenylation is a critical cellular process in eukaryotes. It involves 3′
end cleavage of nascent mRNAs and addition of the poly (A) tail, which plays important roles …

Alternative polyadenylation (APA) of mRNAs has emerged as an important mechanism for
post-transcriptional gene regulation in higher eukaryotes. Although microarrays have …

The hippocampal expression profiles of wild-type mice and mice transgenic for δC-
doublecortin-like kinase were compared with Solexa/Illumina deep sequencing technology …

The genome of Trypanosoma brucei, the causative agent of African trypanosomiasis, was
published five years ago, yet identification of all genes and their transcripts remains to be …

The enormous complexity of biological systems at the molecular level must be answered
with powerful computational methods. Computational biology is a young field, but has seen …

The choice for a polyadenylation site determines the length of the 3′-untranslated region
(3′-UTRs) of an mRNA. Inclusion or exclusion of regulatory sequences in the 3′-UTR may …

Many RNA-binding proteins (RBPs) regulate both alternative exons and poly (A) site
selection. To understand their regulatory principles, we developed expressRNA, a web …