S Lee, J Rauch, W Kolch - International journal of molecular sciences, 2020 - mdpi.com
Mitogen-activated protein kinase (MAPK) pathways represent ubiquitous signal transduction pathways that regulate all aspects of life and are frequently altered in disease. Here, we …
JA Kemp, YJ Kwon - Nano convergence, 2021 - Springer
Modern medicine has been waging a war on cancer for nearly a century with no tangible end in sight. Cancer treatments have significantly progressed, but the need to increase …
Summary Protein homeostasis, or" proteostasis," is indispensable for a balanced, healthy environment within the cell. However, when natural proteostasis mechanisms are …
The increase in available high-throughput molecular data creates computational challenges for the identification of cancer genes. Genetic as well as non-genetic causes contribute to …
S Taefehshokr, A Parhizkar, S Hayati… - … -Research and Practice, 2022 - Elsevier
Although cancer immunotherapy has taken center stage in mainstream oncology inducing complete and long-lasting tumor regression, only a subset of patients receiving treatment …
V Parreno, AM Martinez, G Cavalli - Cell research, 2022 - nature.com
Cancer arises from a multitude of disorders resulting in loss of differentiation and a stem cell- like phenotype characterized by uncontrolled growth. Polycomb Group (PcG) proteins are …
During cancer evolution, constituent tumor cells compete under dynamic selection pressures. Phenotypic variation can be observed as intratumor heterogeneity, which is …
Inherent or acquired resistance to sotorasib poses a substantialt challenge for NSCLC treatment. Here, we demonstrate that acquired resistance to sotorasib in isogenic cells …
Y Shlyakhtina, KL Moran, MM Portal - Cancers, 2021 - mdpi.com
Simple Summary Our manuscript summarizes the up-to-date data on the complex and dynamic nature of adaptation mechanisms and evolutionary processes taking place during …