Yeast cells can respond to growth on relatively poor nitrogen sources by increasing
expression of the enzymes for the synthesis of glutamate and glutamine and by increasing …

Neuronal precursor cell-expressed developmentally downregulated 4 (Nedd4) is the
prototypical protein in a family of E3 ubiquitin ligases that have a common domain …

Many plasma membrane transporters in yeast are endocytosed in response to excess
substrate or certain stresses and degraded in the vacuole. Endocytosis invariably requires …

In addition to its well-known role in recognition by the proteasome, ubiquitin-conjugation is
also involved in downregulation of membrane receptors, transporters and channels. In most …

Gap1p, the general amino acid permease of Saccharomyces cerevisiae, is regulated by
intracellular sorting decisions that occur in either Golgi or endosomal compartments …

It was known that the uptake of tryptophan is reduced in the yeast erg6 mutant, which is
defective in a late step of ergosterol biosynthesis. Here, we show that this is because the …

In yeast, ubiquitin plays a central role in proteolysis of a multitude of proteins and serves
also as a signal for endocytosis of many plasma membrane proteins. We showed previously …

Ubiquitylation of membrane proteins has gained considerable interest in recent years. It has
been recognized as a signal that negatively regulates the cell surface expression of many …

The regulation of nutrient uptake into cells is important, as it allows to either increase
biomass for cell growth or to preserve homoeostasis. A key strategy to adjust cellular nutrient …

Saccharomyces cerevisiae Rsp5 is an essential HECT ubiquitin ligase involved in several
biological processes. To gain further insight into regulation of this enzyme, we identified …