The understanding of the nucleotide/P2 receptor system in the regulation of renal
hemodynamics and transport function has grown exponentially over the last 20 yr. This …

Nucleotides are key subunits for nucleic acids and provide energy for intracellular
metabolism. They can also be released from cells to act physiologically as extracellular …

The involvement of purinergic signalling in kidney physiology and pathophysiology is rapidly
gaining recognition and this is a comprehensive review of early and recent publications in …

Intracellular ATP is the most vital source of cellular energy for biologic systems, whereas
extracellular ATP is a multifaceted mediator of several cell functions via its interaction, in an …

Purinergic signaling within the kidney is becoming an important focus in the study of renal
health and disease. The effectors of ATP signaling, the P2Y and P2X receptors, are …

The regulation of extracellular fluid volume is a key component of blood pressure
homeostasis. Long‐term blood pressure is stabilized by the acute pressure natriuresis …

Decompensation in heart failure occurs when the heart fails to balance venous return with
cardiac output, leading to fluid congestion and contributing to mortality. Decompensated …

Autocrine and paracrine signaling in the kidney adds an extra level of diversity and
complexity to renal physiology. The extensive scientific production on the topic precludes …

Nitric oxide (NO) regulates renal function. Luminal flow stimulates NO production in the thick
ascending limb (TAL). Transient receptor potential vanilloid 4 (TRPV4) is a mechano …

The transient receptor potential melastatin type 6 (TRPM6) ion channel regulates the body
Mg 2+ homeostasis by mediating transcellular Mg 2+ absorption in kidney and intestine …