The extracellular signal-related kinases (ERKs) act as pleiotropic molecules in tumors,
where they activate pro-survival pathways leading to cell proliferation and migration, as well …

B7H3 (also known as CD276, an immune checkpoint molecule) is aberrantly overexpressed
in many types of cancer, and such upregulation is generally associated with a poor clinical …

Emerging evidence has validated the vital role of long non‐coding RNA (lnc RNA) in the
chemoresistance of cancer treatment. In the present study, we investigate the function of lnc …

Introduction The development and prognosis of HCC involve complex molecular
mechanisms, which affect the effectiveness of its treatment strategies. Tumor mutational …

Background Cartilage oligomeric matrix protein (COMP) is known to promote fibrosis in skin,
lung and liver. Emerging evidence shows that COMP plays critical roles in tumor …

Cancer metabolism research has recently been revived and its focus expanded from
glucose and the Warburg's effects on other nutrients, such as glutamine. The underlying …

Most primary liver cancer (PLC) cases progress mainly due to underlying chronic liver
inflammation, yet the underlying mechanisms of inflammation-mediated PLC remain …

Hepatocellular carcinoma (HCC) remains the primary cause of cancer-related death.
Metabolic change is the major characteristic of cancer. The present study attempted to …

Transcription factor E26 transformation specific sequence 1 (ETS-1) is a primary regulator in
the metastasis of human cancer cells, especially hepatocellular carcinoma (HCC) cells; and …

A major cause of oxaliplatin chemoresistance in colorectal cancer (CRC) is acquired
epithelial-mesenchymal transition (EMT) in cancer cells, making the cancer cells easy to …