[HTML][HTML] Potassium channels, tumorigenesis and targeted drugs

C Xia, C Liu, S Ren, Y Cai, Q Zhang, C Xia - Biomedicine & …, 2023 - Elsevier
Potassium channels play an important role in human physiological function. Recently,
various molecular mechanisms have implicated abnormal functioning of potassium …

14-3-3 proteins regulate cullin 7-mediated Eag1 degradation

CH Hsieh, CC Chou, YC Fang, PH Hsu, YH Chiu… - Cell & Bioscience, 2023 - Springer
Background Mutations in the human gene encoding the neuron-specific Eag1 (KV10. 1;
KCNH1) potassium channel are linked to congenital neurodevelopmental diseases …

Structure-Function Studies of Sponge-Derived Compounds on the Cardiac CaV3.1 Channel

AS Depuydt, PA Patel, Ž Toplak, C Bhat… - International journal of …, 2023 - mdpi.com
T-type calcium (CaV3) channels are involved in cardiac automaticity, development, and
excitation–contraction coupling in normal cardiac myocytes. Their functional role becomes …

Theoretical Evaluation of Furanone and its Derivatives for the Treatment of Cancer Through Eag-1 Inhibition.

M Alvarez-Ramirez… - Clinical Cancer …, 2023 - search.ebscohost.com
Several studies suggest that some drugs such as astemizole and tetrandine can inhibit the
expression of Eag-1 in cancer cells. Analyzing these data, this study aimed to evaluate the …

Conopeptides as tools for studying pacemaker channels and for the development of novel cardiovascular drugs

AS Depuydt, J Tytgat, S Peigneur - 2022 - lirias.kuleuven.be
Cardiovascular diseases are the leading cause of death in the world, accounting for the
death of 17.9 million people every year. Based on data from the World Health Organization …