Ovarian cancer is the deadliest gynecological cancer, leading to over 152,000 deaths each
year. A late diagnosis is the primary factor causing a poor prognosis of ovarian cancer and …

Glycomics aims to identify the structure and function of the glycome, the complete set of
oligosaccharides (glycans), produced in a given cell or organism, as well as to identify …

Despite recent progress in understanding the cancer genome, there is still a relative delay in
understanding the full aspects of the glycome and glycoproteome of cancer. Glycobiology …

Simple and complex carbohydrates (glycans) have long been known to play major
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …

Over three decades have passed since the first report on the expression of CA125 by
ovarian tumors. Since that time our understanding of ovarian cancer biology has changed …

Introduction: MUC16 is overexpressed in multiple cancers and plays an important role in
tumorigenicity and acquired resistance to therapy. Area covered: In this review, we describe …

Alteration of glycosylation, a hallmark of cancer, results in the production of tumor-
associated glycans or glycoproteins. These molecules are subsequently secreted or …

Background: Cancer has profound effects on gene expression, including a cell's
glycosylation machinery. Thus, tumors produce glycoproteins that carry oligosaccharides …

Background One of the new roles for enzymes in personalized medicine builds on a rational
approach to cancer biomarker discovery using enzyme-associated aberrant glycosylation. A …

Background While the underlying causes of cancer are genetic modifications, changes in
cellular states mediate cancer development. Tumor cells display markedly changed …