Extensive research has shown that interleukin 6 (IL-6) is a multifunctional molecule that is
both proinflammatory and anti-inflammatory, depending on the context. Here, we combine …

Exercise stimulates the release of proteins with autocrine, paracrine, or endocrine functions
produced in skeletal muscle, termed myokines. Based on the current state of knowledge, the …

Oxidative phosphorylation (OXPHOS) consumes oxygen to produce ATP. However, the
mechanism that balances OXPHOS activity and intracellular oxygen availability remains …

Exhaustive exercise induces systemic inflammatory responses, which are associated with
exercise-induced tissue/organ damage, but the sources and triggers are not fully …

The health benefits of regular exercise are well established. Nonetheless, the molecular
mechanism (s) responsible for exercise-induced health benefits remain a topic of debate …

In the midst of an obesity epidemic, the promotion of brown adipose tissue (BAT) function
and the browning of white adipose tissue (WAT) have emerged as promising therapeutic …

Browning of white adipose tissue is a cold-induced phenomenon in rodents, constituted by
the differentiation of a subset of thermogenic adipocytes among existing white adipocytes …

Background Interventions to preserve functional capacities at advanced age are becoming
increasingly important. So far, exercise provides the only means to counteract age‐related …

The need for effective and convenient ways of combatting obesity has created great interest
in brown adipose tissue (BAT). However, because adult humans have relatively little …

Background Exercise training, including high-intensity interval training (HIIT), improves
rheumatoid arthritis (RA) inflammatory disease activity via unclear mechanisms. Because …