Mendelian randomization
Mendelian randomization (MR) is a term that applies to the use of genetic variation to
address causal questions about how modifiable exposures influence different outcomes …
address causal questions about how modifiable exposures influence different outcomes …
Mendelian randomization: concepts and scope
RC Richmond, GD Smith - Cold Spring …, 2022 - perspectivesinmedicine.cshlp.org
Mendelian randomization (MR) is a method of studying the causal effects of modifiable
exposures (ie, potential risk factors) on health, social, and economic outcomes using genetic …
exposures (ie, potential risk factors) on health, social, and economic outcomes using genetic …
Evaluating the causal relationship between educational attainment and mental health
We investigate the causal relationship between educational attainment (EA) and mental
health using two research designs. First, we compare the relationship between EA and 18 …
health using two research designs. First, we compare the relationship between EA and 18 …
Socioeconomic inequalities in cardiovascular disease: a causal perspective
Socioeconomic inequalities in cardiovascular disease (CVD) persist in high-income
countries despite marked overall declines in CVD-related morbidity and mortality. After …
countries despite marked overall declines in CVD-related morbidity and mortality. After …
Managing the exponential growth of mendelian randomization studies
Much of the research we publish relates to questions of cause and effect. In an ideal world,
we would subject these questions to experimentation, randomizing study participants to …
we would subject these questions to experimentation, randomizing study participants to …
The association between education and premature mortality in the Chinese population: a 10-year cohort study
J Wang, Z Zhao, J Yang, M Ng, M Zhou - The Lancet Regional Health …, 2024 - thelancet.com
Background Recent studies have shown significant associations between education and
premature mortality. However, the relationship differs across countries. We aimed to present …
premature mortality. However, the relationship differs across countries. We aimed to present …
Educational attainment and psychiatric diagnoses: a national registry data and two-sample Mendelian randomization study
We investigate the causal relationship between educational attainment (EA) and mental
health conditions using two research designs. Here we first compare the relationship …
health conditions using two research designs. Here we first compare the relationship …
Disentangling potential causal effects of educational duration on well-being, and mental and physical health outcomes
BackgroundExtensive research has focused on the potential benefits of education on
various mental and physical health outcomes. However, whether the associations reflect a …
various mental and physical health outcomes. However, whether the associations reflect a …
Smoking and BMI mediate the causal effect of education on lower back pain: observational and Mendelian randomization analyses
Z Xu, L Qi, H Zhang, D Yu, Y Shi, Y Yu… - Frontiers in …, 2024 - frontiersin.org
Objective Low back pain (LBP) has been associated with education in previous
observational studies, but the causality remains unclear. This study aims to assess the …
observational studies, but the causality remains unclear. This study aims to assess the …
Using Counterfactual Worlds to Triangulate Evidence in the Real World
JA Labrecque, SA Swanson - Current Epidemiology Reports, 2024 - Springer
Abstract Purpose of Review When a causal question can be reasonably approached using
more than one set of causal assumptions (ie, using different identification strategies) …
more than one set of causal assumptions (ie, using different identification strategies) …