Osteoarthritis: pathogenic signaling pathways and therapeutic targets

Q Yao, X Wu, C Tao, W Gong, M Chen, M Qu… - Signal transduction and …, 2023 - nature.com
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …

Inflammaging and osteoarthritis

F Motta, E Barone, A Sica, C Selmi - Clinical Reviews in Allergy & …, 2023 - Springer
Osteoarthritis is a highly prevalent disease particularly in subjects over 65 years of age
worldwide. While in the past it was considered a mere consequence of cartilage degradation …

Prevalence trends of site‐specific osteoarthritis from 1990 to 2019: findings from the global burden of disease study 2019

H Long, Q Liu, H Yin, K Wang, N Diao… - Arthritis & …, 2022 - Wiley Online Library
Objective To estimate systematic and anatomic site–specific age‐standardized prevalence
rates (ASRs) and analyze the secular trends of osteoarthritis (OA) at global, regional, and …

Knee osteoarthritis: epidemiology, pathogenesis, and mesenchymal stem cells: what else is new? An update

R Giorgino, D Albano, S Fusco, GM Peretti… - International journal of …, 2023 - mdpi.com
Osteoarthritis (OA) is a chronic disease and the most common orthopedic disorder. A vast
majority of the social OA burden is related to hips and knees. The prevalence of knee OA …

Global, regional, and national burden of osteoarthritis, 1990–2020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021

JD Steinmetz, GT Culbreth, LM Haile… - The Lancet …, 2023 - thelancet.com
Background Osteoarthritis is the most common form of arthritis in adults, characterised by
chronic pain and loss of mobility. Osteoarthritis most frequently occurs after age 40 years …

[HTML][HTML] Articular cartilage and osteochondral tissue engineering techniques: Recent advances and challenges

W Wei, H Dai - Bioactive materials, 2021 - Elsevier
In spite of the considerable achievements in the field of regenerative medicine in the past
several decades, osteochondral defect regeneration remains a challenging issue among …

Global, regional and national burden of osteoarthritis 1990-2017: a systematic analysis of the Global Burden of Disease Study 2017

S Safiri, AA Kolahi, E Smith, C Hill… - Annals of the …, 2020 - ard.bmj.com
Objectives To report the level and trends of prevalence, incidence and years lived with
disability (YLDs) for osteoarthritis (OA) in 195 countries and territories from 1990 to 2017 by …

The role of macrophage subtypes and exosomes in immunomodulation

AT Gharavi, NA Hanjani, E Movahed… - Cellular & molecular …, 2022 - Springer
Macrophages are influential members of the innate immune system that can be reversibly
polarized by different microenvironment signals. Cell polarization leads to a wide range of …

Surgical and tissue engineering strategies for articular cartilage and meniscus repair

H Kwon, WE Brown, CA Lee, D Wang… - Nature Reviews …, 2019 - nature.com
Injuries to articular cartilage and menisci can lead to cartilage degeneration that ultimately
results in arthritis. Different forms of arthritis affect~ 50 million people in the USA alone, and it …

[HTML][HTML] An updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and Economic Aspects of …

O Bruyère, G Honvo, N Veronese, NK Arden… - Seminars in arthritis and …, 2019 - Elsevier
Abstract Objectives The European Society for Clinical and Economic Aspects of
Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) sought to revisit the …