Unfolding the cascade of SERPINA3: Inflammation to cancer
A Soman, SA Nair - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2022 - Elsevier
Abstract SERine Protease INhibitor clade A member 3 (SERPINA3), a member of the
SERine-Protease INhibitor (SERPIN) superfamily, principally works as a protease inhibitor in …
SERine-Protease INhibitor (SERPIN) superfamily, principally works as a protease inhibitor in …
Schizophrenia is defined by cell-specific neuropathology and multiple neurodevelopmental mechanisms in patient-derived cerebral organoids
Due to an inability to ethically access developing human brain tissue as well as identify
prospective cases, early-arising neurodevelopmental and cell-specific signatures of …
prospective cases, early-arising neurodevelopmental and cell-specific signatures of …
Current state of modeling human psychiatric disorders using zebrafish
FV Costa, TO Kolesnikova, DS Galstyan… - International Journal of …, 2023 - mdpi.com
Psychiatric disorders are highly prevalent brain pathologies that represent an urgent, unmet
biomedical problem. Since reliable clinical diagnoses are essential for the treatment of …
biomedical problem. Since reliable clinical diagnoses are essential for the treatment of …
Towards precision medicine for pain: diagnostic biomarkers and repurposed drugs
AB Niculescu, H Le-Niculescu, DF Levey… - Molecular …, 2019 - nature.com
We endeavored to identify objective blood biomarkers for pain, a subjective sensation with a
biological basis, using a stepwise discovery, prioritization, validation, and testing in …
biological basis, using a stepwise discovery, prioritization, validation, and testing in …
[HTML][HTML] Semaphorin 6D tunes amygdalar circuits for emotional, metabolic, and inflammatory outputs
Y Nakanishi, M Izumi, H Matsushita, Y Koyama, D Diez… - Neuron, 2024 - cell.com
Regulated neural-metabolic-inflammatory responses are essential for maintaining
physiological homeostasis. However, the molecular machinery that coordinates neural …
physiological homeostasis. However, the molecular machinery that coordinates neural …
Schizophrenia endothelial cells exhibit higher permeability and altered angiogenesis patterns in patient-derived organoids
Schizophrenia (SCZ) is a complex neurodevelopmental disorder characterized by the
manifestation of psychiatric symptoms in early adulthood. While many research avenues into …
manifestation of psychiatric symptoms in early adulthood. While many research avenues into …
Two subtypes of schizophrenia identified by an individual-level atypical pattern of tensor-based morphometric measurement
Difficulties in parsing the multiaspect heterogeneity of schizophrenia (SCZ) based on current
nosology highlight the need to subtype SCZ using objective biomarkers. Here, utilizing a …
nosology highlight the need to subtype SCZ using objective biomarkers. Here, utilizing a …
Increased RNA editing in maternal immune activation model of neurodevelopmental disease
The etiology of major neurodevelopmental disorders such as schizophrenia and autism is
unclear, with evidence supporting a combination of genetic factors and environmental …
unclear, with evidence supporting a combination of genetic factors and environmental …
INFERNO: inferring the molecular mechanisms of noncoding genetic variants
The majority of variants identified by genome-wide association studies (GWAS) reside in the
noncoding genome, affecting regulatory elements including transcriptional enhancers …
noncoding genome, affecting regulatory elements including transcriptional enhancers …
Brain-immune interactions in neuropsychiatric disorders: Lessons from transcriptome studies for molecular targeting
Understanding the pathophysiological mechanisms of neuropsychiatric disorders has been
a challenging quest for neurobiologists. Recent years have witnessed enormous …
a challenging quest for neurobiologists. Recent years have witnessed enormous …