Background Alopecia areata is a disorder that results in nonscarring hair loss. The
psychological impact can be significant, leading to feelings of depression and social …

Mast cells are best recognized for their role in allergy and anaphylaxis, but increasing
evidence supports their role in neurogenic inflammation leading to pain and itch. Mast cells …

Mast cells are well known for their role in allergic and anaphylactic reactions, as well as their
involvement in acquired and innate immunity. Increasing evidence now implicates mast cells …

This review presents evidence that the skin mast cell, in particular the MCTC subtype, is the
primary effector cell in urticaria. Mast cells are located in the upper dermis, the ideal situation …

The discovery of corticotropin-releasing factor (CRF) or CRH defining the upper regulatory
arm of the hypothalamic-pituitary-adrenal (HPA) axis, along with the identification of the …

The intricate relationship between stress and skin conditions has been documented since
ancient times. Recent clinical observations also link psychological stress to the onset or …

Various psychosocial factors have been implicated in the etiology and pathogenesis of
certain cardiovascular diseases such as atherosclerosis, now considered to be the result of …

The classical observations of the skin as a target for melanotropins have been
complemented by the discovery of their actual production at the local level. In fact, all of the …

The subject of neuroinflammation is reviewed. In response to psychological stress or certain
physical stressors, an inflammatory process may occur by release of neuropeptides …

This review focuses on the role of the peripheral nervous system in cutaneous biology and
disease. During the last few years, a modern concept of an interactive network between …