Simple Summary Today, the vast majority of deaths from cancer are due to cancer
metastasis. Metastasis requires that cancer cells escape from the initial tumor, travel through …

Background Focal adhesion serves as a bridge between tumour cells and the extracellular
matrix (ECM) and has multiple roles in tumour invasion, migration, and therapeutic …

Simple Summary Extramedullary multiple myeloma (EMM) is a rare and aggressive subtype
of multiple myeloma which is associated with a poor prognosis. Here, we used mass …

Abstract Background Genes in the Ras pathway have somatic mutations in at least 60% of
colorectal cancers. Despite activating the same pathway, the BRAF V600E mutation and the …

Abstract The Fscn2 (Fascin2) gene encodes an actin cross-linking protein that is involved in
the formation of hair cell stereocilia and retina structure. Mutations in Fscn2 gene have been …

Risk gene identification has attracted much attention in the past two decades. Since most
genes need to be translated into proteins and cooperate with other proteins to form protein …

Background Traditional biomarkers of chronic kidney disease (CKD) detect the disease in its
late stages and hardly predict associated vascular damage. Integrin-linked kinase (ILK) is a …

Background: Bladder cancer (BC) is a common cause of cancer-relevant deaths globally.
This study is designed to delve into expressions, biological functions and molecular …

Abstract Background/Aim: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive
malignancy with dismal prognosis. Genomic instability due to defects in cell-cycle …

Beta-Parvin (PARVB) is an actin-binding protein with functionality in extracellular matrix
binding. Recent studies suggest its potential as a biomarker for various cancers, given its …