Somatic cells that change from one mature phenotype to another exhibit the property of
plasticity. It is increasingly clear that epithelial and endothelial cells enjoy some of this …

A large proportion of the cytoplasm of vertebrate cells, normal or transformed, is represented
by components of the cytoskeleton, including actin-containing microfilaments, tubulin …

The ability of carcinomas to invade and to metastasize largely depends on the degree of
epithelial differentiation within the tumors, ie, poorly differentiated being more invasive than …

A clinicopathologic and immunohistochemical review was madeof 24 cases of distinctive
nerve sheath tumors located in the gastrointestinal tract. The tumors were microscopically …

Monoclonal antibody HEA125 was used to study the tissue distribution of an epithelial cell
surface glycoprotein of M r 34,000 (Egp34). A large panel of normal and neoplastic tissues …

Keratin immunoreactivity in the benign and neoplastic human prostate was examined
immunohistochemically using two monoclonal antibodies with differing specificities. One of …

The keratins are a highly heterogeneous group of proteins that form intermediate filaments
in a wide variety of epithelial cells. These proteins can be divided into at least seven major …

Human epithelial cells contain, intermediate-sized filaments formed by polypeptides related
to epidermal α-keratin (“cytokeratins”) which are expressed in different combinations in …

Metastasis and recurrence are the leading cause of mortality due to breast cancer, but the
underlying mechanisms are still poorly understood. Understanding the breast cancer …

Cytokeratins are a large multigene family comprising two polypeptide types, ie acidic (type I)
and basic (type II) ones, which are distinguished on the basis of immunological, peptide …