Stroke is the leading cause of disability and thesecond leading cause of death worldwide.
With the global population aged 65 and over growing faster than all other age groups, the …

As the major regulator of vascular homeostasis, the endothelium exerts a number of
vasoprotective effects, such as vasodilation, suppression of smooth muscle cell growth, and …

One early phase of atherosclerosis involves the recruitment of inflammatory cells from the
circulation and their transendothelial migration. This process is predominantly mediated by …

Pleiotropic effects of a drug are actions other than those for which the agent was specifically
developed. These effects may be related or unrelated to the primary mechanism of action of …

Background—Inflammatory processes have fundamental roles in stroke in both the etiology
of ischemic cerebrovascular disease and the pathophysiology of cerebral ischemia. We …

Objective—Pleiotropic atheroprotective effects of HMG-CoA reductase inhibitors may be
mediated on the level of vascular gene transcription. The aim of this study was to …

The 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase inhibitors, more
commonly known as statins, are a class of drug widely used for the treatment of …

1. Introduction cholesterol lowering effect. Nevertheless, quite recently, the statins were
found to exert direct cardiovascular effects In 1976, Endo et al.[1] reported on the discovery …

Statins are a class of drugs widely used worldwide to manage hypercholesterolemia and the
prevention of secondary heart attacks. Currently, available statins vary in terms of their …

Cytokines are produced in a variety of tissues and regulate the expression of a number of
inflammatory molecules, leading to destabilization and finally rupture of vulnerable …