Fluorouracil (5-FU) is widely used in the treatment of cancer. Over the past 20 years,
increased understanding of the mechanism of action of 5-FU has led to the development of …

The polyamines spermidine and spermine and their diamine precursor putrescine are
naturally occurring, polycationic alkylamines that are essential for eukaryotic cell growth …

Fluorouracil (5-FU) remains the first-line treatment for colorectal cancer (CRC). Although 5-
FU initially de-bulks the tumor mass, recurrence after chemotherapy is the barrier to effective …

Although p53-mediated cell-cycle arrest, senescence, and apoptosis remain critical barriers
to cancer development, the emerging role of p53 in cell metabolism, oxidative responses …

Background Gastrointestinal mucosal injury (mucositis), commonly affecting the oral cavity,
is a clinically significant yet incompletely understood complication of cancer chemotherapy …

Chemogenomics is an emerging discipline that combines the latest tools of genomics and
chemistry and applies them to target and drug discovery. Its strength lies in eliminating the …

FXYD proteins belong to a family of small-membrane proteins. Recent experimental
evidence suggests that at least five of the seven members of this family, FXYD1 …

Radiotherapy and chemotherapy disrupt bone vasculature, but the underlying causes and
mechanisms enabling vessel regeneration after bone marrow (BM) transplantation remain …

Tanshinone IIA is a derivative of phenanthrene‐quinone isolated from Danshen, a widely
used Chinese herbal medicine. It has antioxidant properties and cytotoxic activity against …

Abstract c-FLIP inhibits caspase 8 activation and apoptosis mediated by death receptors
such as Fas and DR5. We studied the effect of c-FLIP on the apoptotic response to …