Studying temporal dynamics of single cells: expression, lineage and regulatory networks
Learning how multicellular organs are developed from single cells to different cell types is a
fundamental problem in biology. With the high-throughput scRNA-seq technology …
fundamental problem in biology. With the high-throughput scRNA-seq technology …
[HTML][HTML] Reconstructing cell lineage trees with genomic barcoding: approaches and applications
In multicellular organisms, developmental history of cell divisions and functional annotation
of terminal cells can be organized into a cell lineage tree (CLT). The reconstruction of the …
of terminal cells can be organized into a cell lineage tree (CLT). The reconstruction of the …
sciCSR infers B cell state transition and predicts class-switch recombination dynamics using single-cell transcriptomic data
Class-switch recombination (CSR) is an integral part of B cell maturation. Here we present
sciCSR (pronounced 'scissor', single-cell inference of class-switch recombination), a …
sciCSR (pronounced 'scissor', single-cell inference of class-switch recombination), a …
Startle: a star homoplasy approach for crispr-cas9 lineage tracing
CRISPR-Cas9-based genome editing combined with single-cell sequencing enables the
tracing of the history of cell divisions, or cellular lineage, in tissues and whole organisms …
tracing of the history of cell divisions, or cellular lineage, in tissues and whole organisms …
Machine learning based lineage tree reconstruction improved with knowledge of higher level relationships between cells and genomic barcodes
A Prusokiene, A Prusokas… - NAR Genomics and …, 2023 - academic.oup.com
Tracking cells as they divide and progress through differentiation is a fundamental step in
understanding many biological processes, such as the development of organisms and …
understanding many biological processes, such as the development of organisms and …